Chem150 - Survey of Biochemistry • Introduction
Introduction • The chemistry we will focus on this semester • Organic Chemistry • The chemistry of carbon • Functional groups • Biochemistry • The chemistry of living systems
Organic Chemistry • Hydrocarbons represent the starting point • Contain only carbon and hydrogen • Groups include Alkanes, alkenes and alkynes Butane
Organic Chemistry • Organic molecule are organized into functional groups • Many contain elements other than carbon and hydrogen • Oxygen • Nitrogen • Sulfur • Halogens (F, Cl, Br, & I)
Organic Chemistry • Functional Groups • Hydroxyl groups (alcohols) Hydroxyl Group 1-Butanol
Organic Chemistry • Functional Groups • Amino groups (amines) Amino Group 1-Butylamine
Organic Chemistry • Functional Groups • Carbonyl groups (aldehydes and ketones) Aldehyde Group Butanal
Organic Chemistry • Functional Groups • Carboxyl groups (carboxylic acids) Carboxyl Group Butanoic acid
Organic Chemistry • Functional Groups • Functional group affect the physical and chemical properties of organic molecules. Butane (alkane) Butanol (alcohol) Butylamine (amine) Butanoic acid (carboxylic acid) water Butanal (aldehyde)
Organic Chemistry • Functional Groups • chemical structure affects drug or hormone-receptor interactions
Organic Chemistry • Functional Groups • Is this even possible? Or this? http://www.ftc.gov/opa/2004/04/040429canspam.shtm
THC and “designer” drugs: is there a case against “Spice” or K2?
THC and “designer” drugs D9 tetrahydrocannabinol Anandamide JWH-018 ?
Nalgene polycarbonates What chemical questions would you want to have answered to decide ?
PHARMACOPHORE IN THE NEWS: Bisphenol A http://e.hormone.tulane.edu/learning/estrogens.html
Biochemistry • Biological molecules • Amino acids and Proteins • Carbohydrates and Polysaccharides • Nucleotides and Nucleic acids • Lipids (Fats, oils)
Biochemistry • Biological molecules • Aminoacids and Proteins Carboxylic Acid Group Amino Group Alanine
Biochemistry • Biological molecules • Carbohydrates and Polysaccharides Glucose
Biochemistry • Biological molecules • Lipids (Fats, oils) Triglyceride
Biochemistry • Biological Macromolecules • Proteins, Polysaccharides and Nucleic Acids • Metabolism • Taking things apart • Putting things together • Obtaining and using energy • Regulation of processes.