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Osler Institute – Pathology Board Review: Electron Microscopy

Osler Institute – Pathology Board Review: Electron Microscopy. EM of Tumors and Tumor-Like Entities. Osler Institute – Pathology Board Review: Electron Microscopy. Acinar Cell Carcinoma Zymogen granules 0.3 – 1.5 microns Stacks of RER Salivary gland Pancreas Pancreaticoblastoma

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Osler Institute – Pathology Board Review: Electron Microscopy

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  1. Osler Institute – Pathology Board Review: Electron Microscopy EM of Tumors and Tumor-Like Entities

  2. Osler Institute – Pathology Board Review: Electron Microscopy • Acinar Cell Carcinoma • Zymogen granules 0.3 – 1.5 microns • Stacks of RER • Salivary gland • Pancreas • Pancreaticoblastoma • Immunopositive for • alpha-1 antitrypsin • Trypsin • Chymotrypsin • Lipase

  3. Osler Institute – Pathology Board Review: Electron Microscopy Adenocarcinoma – extracellular lumina, intestinal type microvilli

  4. Osler Institute – Pathology Board Review: Electron Microscopy • Neoplasms • Adenocarcinoma • Intracytoplasmic lumina • Microvilli • Junctional complexes

  5. Osler Institute – Pathology Board Review: Electron Microscopy Neoplasms

  6. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Bronchioloalveolar Cell carcinoma • Type II Pneumocyte • Myelin figures • Microvilli • Clara Cells • Secretory granules

  7. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Carcinoid (Neuroendocrine) Tumors • Dense core granules • 140 – 400 nm • True lumens • Intracytoplasmic filaments

  8. Electron Microscopy - Osler Institute Pathology Board Review • Eosinophilic Granuloma • Langerhan’s cell histiocyte • Rod shaped Birbeck Granule • Pleomorphic, deeply cleaved nucleus

  9. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Ependymoma • 5 – 7% of intracranial neuroglial neoplasms • 60% of neuroglial tumors in spinal cord • Most common sites – fourth ventricle and lumbosacral region • Flexner type rosettes • True lumens – cilia, microvilli and junctional complexes

  10. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Ependymoma • Junctional complexes • Intracytoplasmic lumina • Intracytoplasmic glial filaments • Immunopositive for GFAP

  11. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Granular Cell Tumor • Pleomorphic secondary lysosomes • Basal lamina around cell groups

  12. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Granular Cell Tumor • Angulate lysosomes in stromal fibrohistiocytic cells

  13. Electron Microscopy - Osler Institute Pathology Board Review Neoplasms • Hibernoma • Lipid droplets • Electron dense mitochondria • S-100 protein + • Vimentin +

  14. Electron Microscopy - Osler Institute Pathology Board Review • Lymphoma • Non Hodgkin's Type • No junctional complexes • Few cytoplasmic organelles • Abundant polyribosomes

  15. Electron Microscopy - Osler Institute Pathology Board Review • Lymphoma • Non Hodgkin's Type • No junctional complexes • Few cytoplasmic organelles • Abundant polyribosomes

  16. Electron Microscopy - Osler Institute Pathology Board Review • Neoplasms • Mesotheliomas • Long thin microvilli • Bipolar cytoplasmic processes • Desmosomes • Primitive junctions • Calretinin + • Mesothelin +

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