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1 mV. familial startle syndrome. Barbiturates Benzodiazepines Alcohol General Anesthetics. Chem. driving force. Elec. driving force. Rasmussen’s Encephalatis. Kainate Receptor. AMPA Receptor. Vc. +. Presynaptic glutamatergic Neuron. Postsynaptic Neuron. Vm = -35 mV.

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1 mV

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  1. 1 mV

  2. familial startle syndrome Barbiturates Benzodiazepines Alcohol General Anesthetics

  3. Chem. driving force Elec. driving force

  4. Rasmussen’s Encephalatis Kainate Receptor AMPA Receptor

  5. Vc + Presynaptic glutamatergic Neuron Postsynaptic Neuron Vm = -35 mV NMDAR EPSC AMPAR EPSC Vm = -70 mV NMDAR EPSC AMPAR EPSC Glutamate receptor excitatory postsynaptic currents (EPSCs)

  6. Hippocampal long-term potentiation

  7. ionotropic receptors metabotropic receptors Effector

  8. Ionotropic receptor synaptic actions Metabotropic receptor synaptic actions Indirect Direct slower (0.1-100 s) fast (ms) open or close channels open synaptic channels resting channels, voltage-gated channels, fast synaptic channels channels only at synapse modulate excitability excite or inhibit AP

  9. ACh closure PIP2 PLC Gq DAG IP3 Ca release Protein kinase C

  10. 1.5 2. Decrease in slow delayed rectifier K current nA 1. Decrease in resting outward K current 0 1. Slow EPSP

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