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Arthritis, Strokes, and Heart Attacks

This article explores the intricate balance between vasodilators like nitric oxide (NO) and vasoconstrictors such as thromboxane A2 (TXA2) in regulating vascular tone. Key factors like arachidonic acid metabolism and the impact of various signaling molecules, including Angiotensin II (ATII) and norepinephrine (NE), on conditions like arthritis, strokes, and heart attacks are discussed. The role of NSAIDs in reducing inflammation by inhibiting PGF2a and proteases, as well as potential therapeutic applications, are also covered.

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Arthritis, Strokes, and Heart Attacks

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  1. Relaxation Contraction PKG PKA PLC GC AC Gq GS COX2 P P TXA2 PGH2 NO L-Arg Vasodilators NO, ANP or Adenosine, PC Vasoconstrictors NE, ET, TXA2, ATII, VP Arthritis, Strokes, and Heart Attacks Arthritis - reduce PGF2a & proteases with NSAIDs Eric Niederhoffer SIU-SOM SMC TXA2 EC PGI2 P VL

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