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Mogens Vestergaard GP, Associate professor, PhD

Epidemiology in General Practice – the Nordic paradise. Mogens Vestergaard GP, Associate professor, PhD. Data collection. Storm P. Modern science (1910). The Nordic paradise. Several important papers. Programme. Nationwide registries - Mogens Vestergaard

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Mogens Vestergaard GP, Associate professor, PhD

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  1. Epidemiology in General Practice– the Nordic paradise A A R H U S U N I V E R S I T Y INSTITUTE OF PUBLIC HEALTH Department of General Practice Mogens Vestergaard GP, Associate professor, PhD

  2. Data collection Storm P. Modern science (1910).

  3. The Nordic paradise

  4. Several important papers

  5. Programme • Nationwide registries • - Mogens Vestergaard • The Danish General Practice Database • Henrik Schroll • Drugs and registers • - Morten Andersen • Population-based cohorts • - Carsten Obel

  6. Nationwide registries

  7. Nationwide registries Civil Registration System

  8. Nationwide registries National Presciption Registry Danish General Practice Database National Health Service PKU register Civil Registration System Cause of death register National Hospital Register Psykiatric Central Register Statistic Denmark Medical Birth Register

  9. Childhood vaccinations – an example

  10. MRR-vaccine was introduced MMR and Autism WakefieldLancet 1998 Timing of symptoms

  11. Vaccination cohort • Registries • Civil Registration system, Central psychiatric Register, National Hospital Register, Medical Birth Register, National Health Service • Cohort • Danish children born 1991-1998 (N= 537,000) • MMR vaccinated (N=439,251) • Outcome • Autism (N= 316), Autism spectrum disorder (N= 422) • Febrile seizures (N=17,986)

  12. MMR and Autism

  13. MMR and febrile seizures

  14. Age at MMR vaccination MRR vaccination

  15. MMR and Febrile seizures – relative risk

  16. MMR and Febrile seizures – absolute risk

  17. Stress and childhood cancer - an example

  18. Stress and childhood cancer • Maternal bereavement • Child • Partner • Sibling • Parent Childhood cancer Prenatal Postnatal

  19. Scandinavian registries Finland Denmark Stress and cancer Sweden

  20. Registerbased research - strenght • Size matters

  21. Registerbased research - strenght Sizematters Noselection bias

  22. Registerbased research - strenght • Sizematters • Noselection bias • Data is collectedprospectively

  23. Registerbased research - strenght • Sizematters • Noselection bias • Data is collectedprospectively • The researcher do not influence data collection

  24. Registerbased research - strenght • Sizematters • Noselection bias • Data is collectedprospectively • The researcher do not influence data collection • Data alreadyexists

  25. Registerbased research - weaknesses Data quality

  26. Registerbased research - weaknesses Data quality

  27. Registerbased research - weaknesses Data quality Heavy computer skillsareneeded

  28. Registerbased research - weaknesses Data quality Heavy computer skillsareneeded Statisticalsignificantresultsneed not bebiological relevant

  29. Registerbased research - weaknesses Data quality Heavy computer skillsareneeded Statisticalsignificantresultsneed not bebiological relevant Lack of important variables

  30. Registerbased research Use it but look out for the pitfalls

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