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An update from the JSM 2006 - Seattle

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Toxicokinetic Calculations

Toxicokinetic Calculations. Extent of distribution The parameter that reflects the extent of distribution is the apparent volume of distribution, V d , where: V d = Dose/C p,0

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Toxicokinetic Calculations

Toxicokinetic Calculations. Extent of distribution The parameter that reflects the extent of distribution is the apparent volume of distribution, V d , where: V d = Dose/C p,0

529 views • 52 slides

P rocalcitonin R eveals E arly D ehiscence I n C oloretcal S urgery: the PREDICS Study

P rocalcitonin R eveals E arly D ehiscence I n C oloretcal S urgery: the PREDICS Study. V. GIACCAGLIA. PROCALCITONIN. 116 aminoacid protein, encoded by CALC1 gene produced and secreted by C-cells of the thyroid calcitonin pro-hormone, Ca metabolism.

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Phase 1 Bioavailability(BA)/Bioequivalence(BE) & Fed Studies

Phase 1 Bioavailability(BA)/Bioequivalence(BE) & Fed Studies. Ruth E. Stevens, PhD, MBA Chief Scientific Officer, Executive Vice President Camargo Pharmaceutical Services ACPU: October 19, 2010. Approved Product Labeling. Drug Substance. Indication. Safety. Clinical Pharmacology. DDI.

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433 views • 25 slides

AD Revell , D Wang, R Harrigan, J Gatell, L Ruiz, S Emery,

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Analysis of recent trials/cohort on resistance in Africa

Analysis of recent trials/cohort on resistance in Africa. Annemarie Wensing, MD, PhD. Disclaimer. 10 minutes presentation Not a complete overview on development of resistance in Africa Highlight a selection of interesting data & developments.

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AD Revell , D Wang, R Harrigan, J Gatell, L Ruiz, S Emery,

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Performance measures

Performance measures. Morten Nielsen. Performance measures. Meas Pred 0.4050 0.8344 0.9373 1.0000 0.8161 0.6388 0.6752 0.9841 0.0253 0.0000 0.3196 0.5388 0.6764 0.6247 0.1872 0.1921 0.4220 0.6546 0.6545 0.6546 0.7917 0.1342 0.4405 0.3551 0.1548 0.0000 0.2740 0.1993

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Performance measures

Performance measures. Morten Nielsen, CBS, Department of Systems Biology , DTU. Performance measures. Meas Pred 0.4050 0.8344 0.9373 1.0000 0.8161 0.6388 0.6752 0.9841 0.0253 0.0000 0.3196 0.5388 0.6764 0.6247 0.1872 0.1921 0.4220 0.6546 0.6545 0.6546 0.7917 0.1342

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S100A8 /S100A9

SJIA. SJIA. F. Q. KD. FI. F. Q. KD. FI. Relative DIGE MEASUREMENTS. Relative ELISA MEASUREMENTS. A2M. APOA1. CRP. HP. S100A9. S100A8. SAA. SAP. A2M. APOA1. CRP. HP. S100A8 /S100A9. SAA. SAP. Figure 4. C. A. B. D. Training set n = 24. Testing set n = 20.

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Biomarker panel of 7 members A2M APO AI CRP HP S100A8/S100A9 SAA SAP

B. A. Training set n = 24. Testing set n = 20. Training. Testing. SJIA. Biomarker panel of 7 members A2M APO AI CRP HP S100A8/S100A9 SAA SAP. SJIA. Clinical diagnosis. Clinical diagnosis. SJIA F. SJIA Q. SJIA F. SJIA Q. F. Q. F. Q. 12. 12. 10. 10. n =. n =.

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S100A8 /S100A9

SJIA. SJIA. F. Q. KD. FI. F. Q. KD. FI. Relative DIGE MEASUREMENTS. Relative ELISA MEASUREMENTS. A2M. APOA1. CRP. HP. S100A9. S100A8. SAA. SAP. A2M. APOA1. CRP. HP. S100A8 /S100A9. SAA. SAP. Figure 4. C. A. B. D. Training set n = 24. Testing set n = 20.

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DMD (27- 31 y.a .)

Supplementary Fig.1a. LGMD2B. DMD (27- 31 y.a .). DM1. LGMD. sensitivity. sensitivity. sensitivity. sensitivity. AUC:0.80. AUC:0.65. AUC:0.83. AUC:0.75. 1-specificity. 1-specificity. 1-specificity. 1-specificity. DMRV. BMD. FSHD. sensitivity. sensitivity. sensitivity.

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Supplementary Figure 1

Supplementary Figure 1. D. B. A. C. 3 (51 ? 75%). 2 (26 ? 50%). 1 (1 ? 25%). 4 (76 ? 100%). E. F. G. H. 3 (strong). 2 (moderate). 0 (negative). 1 (weak). Supplementary Figure 2. A. SW480. HT29. C. D. ANGPTL2/GAPDH. ANGPTL2/GAPDH. ANGPTL2/GAPDH. E. B. F. SW480. HT29.

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P394

Introduction.

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