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Drug Design for Inhibition of Extracellular Signal-regulated Kinase 2

Drug Design for Inhibition of Extracellular Signal-regulated Kinase 2. Sam Klingbeil , Nicole Reiff and James Wagner. ERK2. ERK2 is part of a signaling cascade that results in neuronal differentation , mitogenesis , oncogenic transformation and apoptotic cell death.

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187 views • 8 slides

INTRODUCTION

INTRODUCTION.

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116 views • 6 slides

INTRODUCTION

INTRODUCTION.

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65 views • 6 slides

ERK2

apaf-1 -/-. p53. p21. ERK2. TPT (h). C 1 2 4 8. Supplemental Figure 1.

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Supplemental Figure 3

wt apaf-1 -/- p53 -/-. Bcl-2. ERK2. C 16 24 48 C 16 24 48 C 16 24 48. TPT (h). Supplemental Figure 3.

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Supplemental Figure 2

wt apaf-1 -/- p53 -/-. Pro-casp8 p48. unspecific band. ERK2. TPT (h). C 8 24 C 8 24 C 8 24. Supplemental Figure 2.

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Merge

C. A. Flag-MIG-6 V5-ERK2. Control. V5-ERK2. Flag-MIG-6. Flag-MIG-6 - - + + V5-ERK2 - + - +. WB. a. b. c. d. IgG Flag IgG V5. V5 Flag Flag V5 Actin. IP. DAPI. Input. e. f. g. h. Rhodamine (V5). B. i. j. k. l.

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160 views • 1 slides

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Drug Design for Inhibition of Extracellular Signal-regulated Kinase 2

INTRODUCTION

INTRODUCTION

ERK2

Supplemental Figure 3

Supplemental Figure 2

Merge