'Gene regulatory network' diaporamas de présentation

Gene Network Modeling

Gene Network Modeling. Prof. Yasser Kadah Eng. Fadhl Al-Akwaa. OUTLINES. What is the Gene Regulatory Network? GRN Application of GRN GRN Construction Methodology GRN modeling steps GRN Models GRS Software Next work Reference. From The Last Lecture. DNA sequence {A,T,C,G} ATCGAATCGA

1.17k views • 99 slides

Open Science, Open Data, Open Source Projects for Undergraduate Research Experiences

Open Science, Open Data, Open Source Projects for Undergraduate Research Experiences. Kam D. Dahlquist, Ph.D. Department of Biology Loyola Marymount University. BioQUEST/HHMI/CaseNet Summer Workshop June 13, 2015. Outline. An open science ecosystem enhances student learning

581 views • 58 slides

Structure, evolution and dynamics of gene regulatory networks

Structure, evolution and dynamics of gene regulatory networks. M. Madan Babu. Group Leader MRC Laboratory of Molecular Biology, Cambridge. Network. Metabolic. Protein Interaction. Transcriptional. Proteins. Nodes Links. Metabolites. Transcription factor Target genes. Enzymatic

677 views • 52 slides

A Quantitative Overview to Gene Expression Profiling in Animal Genetics

A Quantitative Overview to Gene Expression Profiling in Animal Genetics. Gene Networks. Reversed Engineering (data-driven) of Gene (Regulatory) Networks from Expression Data. Armidale Animal Breeding Summer Course, UNE, Feb. 2006.

647 views • 50 slides

Spaghetti Code, Soupy Logic adventures in gene expression & genome annotation

Spaghetti Code, Soupy Logic adventures in gene expression & genome annotation. Jim Kent University of California Santa Cruz. A Challenge Every Speaker Faces:. Who is the audience? Bioinformaticians: Biologists with bigger, better databases? Geeks trading bits for bases?

614 views • 48 slides

Searching for Sense in the Genome

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By Linglin Huang

Inferring causal genomic alterations in breast cancer using gene expression data ( Linh M Tran et.al). By Linglin Huang. A bstract. Background: identify causal genomic alterations in cancer research many valuable studies lack genomic data to detect CNV

507 views • 35 slides

V4 Full understanding of gene transcription: gene regulatory networks

V4 Full understanding of gene transcription: gene regulatory networks. This lecture is fully based on. Eric H. Davidson (Caltech). D e-Leon, Annu Rev. Biophys Biomol Struct. 36, 191 (2007. Introduction: development of an organism.

482 views • 26 slides

Transcription factor binding sites and gene regulatory network

Transcription factor binding sites and gene regulatory network. Victor Jin Department of Biomedical Informatics The Ohio State University. Transcription in higher eukaryotes. Gene Expression Chromatin structure Initiation of transcription Processing of the transcript

531 views • 25 slides

Impact of Bioinformatics in our life and BME engineer responsibility

Impact of Bioinformatics in our life and BME engineer responsibility . Dr Fadhl Alakwaa fadhl-alakwa.weebly.com. The Central Dogma. 3. 1. 2. 3. Target. Library. Book shelves. Book. 4. Protein Synthesis: DNA, RNA, and the Flow of Information . Replication. Transcription.

328 views • 23 slides

Acknowledgements

Abbreviations. DBD: DNA Binding Domain ; TF: Transcription Factor ; A: Activator ; R: Repressor ; D: Dual Regulator ; U: Unknown regulatory function ; RNAP: RNA Polymerase. Acknowledgements.

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Distribution of DBDs in the TF Regulatory Network

+. _. +. +. _. _. _. metR. iclR. dnaA. _. rhaS. marA. marR. _. uidR. _. metJ. fadR. +. iciA. rhaR. _. _. uxuR. soxS. rob. +. _. exuR. _. lrp. soxR. mlc. +. fecI. +. _. +. +. +. +. +. +. malT. malI. melR. yiaJ. araC. glpR. glnG. gutM. fucR. fur.

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Summary

promoter. gene. p 2. B 1. a 12 , d 12. determine transcription rate. p 3. a 23 , d 23. F k. B 2. p k. a 24 , d 24. p 4. Expression = F k (Q 1 , Q 2 , Q 3 ) , where Q i is state of binding site B i. attach/detach. influence. p 1. B 3. a 31 , d 31. Legend:. p j. B i.

113 views • 1 slides