'Histone modifications' diaporamas de présentation

DNA and Chromosomes

DNA and Chromosomes. DNA, Chromosome Centromere, telomere, replication origin Nucleosome, Chromatin, Histone: H1, H2A, H2B, H3, H4 Histone octamer, DNA packaging DNA binding proteins, Histone modifications. Lampbrush chromosomes (amphibian oocyte).

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Histone Modifications

Histone Modifications. Outline. Overview of histone modifications: Types of modifications and modifiers General roles of modifications Techniques used to study histone modifications Specific modifications (acetylation, methylation, etc ): Residues/positions that are frequently modified

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Histone Analysis Product Overview 2012

Histone Analysis Product Overview 2012. Histones. Histones are alkaline proteins (H2A, H2B, H3 and H4) that package DNA into structural units called nucleosomes.

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Bioinformatic Analysis of Chromatin Genomic Data

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Biol/Chem 473

Biol/Chem 473. Schulze lecture 6: Introduction to chromatin structure. Control regions upstream of pair-rule genes are complex.

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Bioinformatic Analysis of Chromatin Genomic Data

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Epigenetics

Epigenetics. Epigenetics - Heritable changes in gene expression that operate outside of changes in DNA itself - stable changes in gene expression caused by changes in chromatin structure. Epigenetics. DNA methylation Histone tail post-translational modifications microRNA.

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Bio 402/502 Section II, Lecture 2

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Human gene expression and genomic imprinting

Human gene expression and genomic imprinting . Lecture 3.

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TNF superfamily TNF: produced by macrophages, monocytes, lymphocytes, fibroblasts upon inflammation, infection, injury,

TNF superfamily TNF: produced by macrophages, monocytes, lymphocytes, fibroblasts upon inflammation, infection, injury, environmental challenges. Important for innate and adoptive immunity. TNF: inflammatory responses to microbial infections. LT (lymphotoxin):cellular or hymoral immunity

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Organization of DNA Within a Cell

Organization of DNA Within a Cell. 2 meters of DNA is packed into a 10 m m diameter cell. from Lodish et al ., Molecular Cell Biology, 6 th ed. Fig 6-1. Appearance of Chromatin Depends on Salt Concentration. Physiological ionic strength 30 nm fiber. Low ionic strength Beads on a string.

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Intro to Comp Genomics

Intro to Comp Genomics. Lecture 7: Using large scale functional genomics datasets. Your Task. Your Task. Modeling. S. P1. Preparations: Get your hand on the ChIP-seq profiles of CTCF and PolII in hg chr17, bin-size = 50bp Cut the data into segments of 50,000 data points Modeling:

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A more efficient, sensitive & robust method of chromatin immunoprecipitation

A more efficient, sensitive & robust method of chromatin immunoprecipitation. Epigenetics: the study of the organisation and management of the genome. Proteins around which DNA is wound. Epigenetic landscape. Nucleosomes. CHROMOSOME. ME. Will affect health outcomes. Histone Tails.

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Chromatin Remodeling

Chromatin Remodeling. *Cytosine Methylation*. Glossary. Epigenetic: Heritable changes in gene function, not caused by changes in the DNA sequence itself.

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Genome Sequence & Gene Expression

Chromatin & Nuclear Organization. Genome Sequence & Gene Expression . Chromosome Inheritance & Genome Stability . organization of chromosomes & proteins in nucleus . packaging . replication & chromatin assembly. chromatin modifications.

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Challenges in Computational & Functional Genomics

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Announcements

Announcements. Homework 8 due next Wednesday Clicker quiz on Monday, covers Chapter 18 (key terms 11) Next exam: April 18 (Wednesday). BIO 304 Lecture 27. Positive control of the lac operon. The trp operon. Attenuation at the trp operon. Comparison of lac and trp operons.

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Supplemental Figure 1

Supplemental Figure 1. A. B. H3Ac. H3K9Me3. H3S10P. Protein association (ratio to IgG ).

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H Guo et al. Nature 000 , 1-5 (2014) doi:10.1038/nature13544

Relationships between DNA methylation, histone modifications and gene expression. H Guo et al. Nature 000 , 1-5 (2014) doi:10.1038/nature13544.

89 views • 1 slides