Rapamycin treatment - PowerPoint PPT Presentation

A549 KRAS mutant G12S LKB1 null M CDKN2A (p16) M CDKN2a (p14) SMARCA4

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(A)

Blocking peptide. Blocking peptide. rapamycin. rapamycin. ctrl. 6hr. 24hr. ctrl. 6hr. 24hr. (A). (B). mTOR. mTOR. rictor. rictor. raptor. raptor. IP: mTOR. Cho-CK. IP: mTOR. SCK. Cho-CK. Choi-CK. (C). SCK. JCK. ctrl 6hr 24hr. ctrl 6hr 24hr. ctrl 6hr 24hr.

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< Rapamycin treatment for 24 hrs>

< Rapamycin treatment for 24 hrs>. < Rapamycin treatment for 48 hrs>.

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K Araki et al. Nature 000 , 1- 5 (2009) doi:10.1038/nature081 55

Rapamycin treatment during T-cell expansion phase increases the number of memory precursors. K Araki et al. Nature 000 , 1- 5 (2009) doi:10.1038/nature081 55.

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