'Regulatory sequences' diaporamas de présentation

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????. ??? zhangxianning@zju.edu.cn Tel? 13105819271; 88208367 Office: A705, Research Building 2013/09. Learning Objectives. 1. Traditional managements 2. Gene therapy. Treatment of Genetic Disease by Metabolic Manipulation. Wilson disease: Cu toxicity, AR. Wilson SAK. Brain ,

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LECTURE 18: TRANSPOSABLE ELEMENTS

LECTURE 18: TRANSPOSABLE ELEMENTS. chapter 13 exam 2 & grades general ideas discovery in maise prokaryotes eukaryotes dynamic & plentiful host regulation. The Biology Graduate Student Association Presents.

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Homeotic genes in Drosophila body patterning

Homeotic genes in Drosophila body patterning. Department of Biochemistry petros.ligoxygakis@bioch.ox.ac.uk. Developmental biology: Drosophila segmentation and repeated units. * egg: generate the system. * larva: eat and grow. * pupa: structures in larvae grow out to for m

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How and Why Genes Are Regulated

How and Why Genes Are Regulated. Four of the many different types of human cells: They all share the same genome. What makes them different?. Gene Expression. Genes are expressed as traits Traits are proteins or result from reactions which are regulated by proteins, such as enzymes.

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Transposible elements Viruses and viroids

Transposible elements Viruses and viroids. Transposons , TE = mobile genetic elements sequences of DNA that can move around to different positions within the genome of a single cell ( transposition ), cause mutations and chromosomal rearrangements

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Host cells for the production of biopharmaceuticals

Host cells for the production of biopharmaceuticals . Many of biopharmaceuticals, especially proteins : produced by recombinant DNA technology using various expression systems

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Chromatin Remodeling

Chromatin Remodeling. Levels of chromatin organization. 300 nm fiber. nucleosome arrays. Structure of the nucleosome: problems of accessibility for DNA-binding proteins. Histone cores are predominantly alpha helical. Luger et al. (1997) Nature 389, 251.

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V3 Nuclear architecture affects gene regulation

V3 Nuclear architecture affects gene regulation. Eukaryotic genomes are regulated on 3 different levels: On the sequence level (V2). This includes the 1D organization of functional sequence elements in the genome: - coding regions,

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Gene Structure and Identification III

Gene Structure and Identification III. Previous reading: 1.3, 9.1-9.6 10.2, 10.4, 10.6-8. BIO520 Bioinformatics Jim Lund. Solve the protein folding problem Solve the molecular docking/binding problem Develop realistic simulations of molecules in cells Simulate multicellular systems.

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ASSIGNING GENE FUNCTION BY EXPERIMENTAL ANALYSIS

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The Hardwiring of development: organization and function of genomic regulatory systems

The Hardwiring of development: organization and function of genomic regulatory systems. Maria I. Arnone and Eric H. Davidson. Outline: . Introduction Properties of CIS-Regulatory Systems Gene Regulatory Networks Conclusion and Summary. Introduction .

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Motif identification with Gibbs Sampler

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Gene Structure and Gene Expression

Gene Structure and Gene Expression. Each chromosome contains one DNA molecule, which consists of roughly 80 million bases. How these extremely long molecules fit in a nucleus?. They are tightly associated with proteins to form nucleoprotein complex.

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Genomes & their evolution

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Cell to Cell Communication via Steroids & Hormones

Cell to Cell Communication via Steroids & Hormones. Packet #24 Chapter #11. Hormones & Gene Transcription. Hormones & Gene Transcription. Hormones are sometimes used to initiate transcription and translation as a response.

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Motif discovery in co-regulated genes

Motif discovery in co-regulated genes. Jeremy Glasner Genetics 875 December 7, 2007. www.biostat.ucsf.edu/cbmb/bmi209.fall05/fall2004/lectures/bmi209-lecture9.pdf. Transcriptional regulatory regions (cis regulatory elements). From microarrays to regulatory networks.

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Question 1 ___________________________ Question 2 ___________________________

PCB5065 Fall 2012 - Exam 4 - Chase Name __________________________________ page 1 of 4. Question 1 ___________________________ Question 2 ___________________________ Question 3 ___________________________ Total ___________________________ out of 50 points

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ORegAnno: Open Regulatory Annotation (oreganno)

F. B. A. C. G. D. E. A. A. C. C. B. B. D. E. F. G. H. I. D. E. ORegAnno: Open Regulatory Annotation (www.oreganno.org) An open access database and curation system for regulatory sequences. Griffith OL 1,2 , Montgomery SB 1,2 , Sleumer MC 2 , Bergman CM 3 , Bilenky M 2 ,

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