'Theophylline' diaporamas de présentation

Hypokalemia

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Department of Pharmacology

Section 4 Drugs Affecting the Center Nervous System. Department of Pharmacology. Chapter 22 Sedative and hypnotic Drugs. Definitions A sedative drug decreases activity, moderates excitement, and calms the recipient.

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COPD (Chronic Obstructive Pulmonary Disease)

COPD (Chronic Obstructive Pulmonary Disease). Dr. Meg- angela Christi Amores. COPD. Global Initiative for Chronic Obstructive Lung Disease (GOLD) a disease state characterized by airflow limitation that is not fully reversible Includes:

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??? ???? ?????? ?????? Methylxanthines (Theophylline) Toxicity

??? ???? ?????? ?????? Methylxanthines (Theophylline) Toxicity. ?/ ??? ?????? ???? ?????? ??????? ???? ?????? ? ?????? ???????????, ???? ???? ?????? ? ?????? ???????????, ??????? ???? ?????? ??????? ???? ???????. Objectives. Therapeutic uses. Toxicokinetics . Mechanism of toxicity.

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Lab Meeting

Lab Meeting. 09/27/13. Program Update. Unafold arrived Need to install g77 complier. Theophylline Detection Results. How much Theophylline do cells need to grow on plates? . Test growth at 0.4, 0.2, 0.1, 0.05, 0.0 mM of Theophylline Look for visible GFP expression. psB1A2. High copy .

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Drugs For Treating Asthma

Drugs For Treating Asthma. Chapter 9. Sympathomimetic Agents. Noninfectious respiratory diseases are divided into two groups Asthma is characterized by reversible airway obstruction Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airway obstruction

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Coffee

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Lab Meeting

Lab Meeting. 10/04/2013. Results – Theophylline Disc. Ecdm8 + Riboswitch + tetA. Ecdm8 + Riboswitch + tetA. Ecdm8 + Riboswitch + tetA. Constructs on same Plasmid. High Promoter. Low Promoter. Results – Caffeine Disc. Ecdm8 + Riboswitch + tetA. Ecdm8 + Riboswitch + tetA.

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THEOPHYLLINE OVERDOSE

THEOPHYLLINE OVERDOSE. Prof. A. Walubo Department of Pharmacology. Case report. Emergency Dept. A 22-yr-old F, 6 hrs after ingestion of 20 g of S-R theophylline Nausea, Vomiting and palpitations. PMH: Not asthmatic & never used theophylline before Lab: - K + = 2.4 mmol/l;

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Acidic beverage and the bioavailability of theophylline

In this study the effect of acidic beverages (Pepsi) on the bioavailability of theophylline was investigated in healthy rabbits. Assuming an open one compartment model, theophylline suspension (100mg/kg) was administered orally via intragastric tube. Blood samples were withdrawn at time intervals from 0-24hr. after washing period of 7 days, Pepsi (10ml/kg) was administered concomitantly with theophylline (100mg/kg) and then blood samples were taken at similar intervals. Plasma was separated and treated in a specific manner and assayed for theophylline by using high performance liquid chromatography (HPLC). The data calibration curve was constructed and various pharmacokinetic parameters were calculated. Comparisons of data revealed significant differences between the pharmacokinetic parameters for theophylline given alone and with pepsi. The results suggest a significant increase in the bioavailability of theophylline in presence of pepsi that ultimately will lead to the appearance of unwanted side effect and toxic response.

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