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Understanding the PATCHED Gene: Role in Hedgehog Signaling Pathway and Cancer Development

Explore the intricate role of the PATCHED gene in cell fate control through inhibiting Hedgehog signaling, regulating transcription, and influencing the cell cycle. Learn how mutations in this gene are linked to various cancers, including Gorlin Syndrome and basal cell carcinomas.

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Understanding the PATCHED Gene: Role in Hedgehog Signaling Pathway and Cancer Development

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  1. The PATCHED (Ptc) Gene Brendan McQuellon

  2. What is PATCH • Transmembrane surface receptor • Binds ligands of Hedgehog(Hh) family Weinberg, 2007

  3. Normal Ptc Role • Controls cell fate by inhibiting Hh/Shh signaling • Inhibits the transcription of Hh/Shh target genes • Can regulate the cell cycle

  4. Shh/Ptc/Gli pathway http://www.armchairempire.com/images/feature-articles/Weekly-Top-10/pub-crawl/sonic-hedgehog.jpg Weinberg, 2007

  5. Shh/Ptc/Gli pathway http://www.armchairempire.com/images/feature-articles/Weekly-Top-10/pub-crawl/sonic-hedgehog.jpg Weinberg, 2007

  6. Sonic hedgehog and Patched regulate neural development http://scienceblogs.com/pharyngula/2007/03/basics_neurulation.php www.pressthebuttons.com/

  7. Sonic hedgehog and Patched regulate neural development http://scienceblogs.com/pharyngula/2007/03/basics_neurulation.php www.pressthebuttons.com/

  8. Sonic hedgehog and Patched regulate neural development http://scienceblogs.com/pharyngula/2007/03/basics_neurulation.php www.pressthebuttons.com/

  9. Sonic hedgehog and Patched regulate neural development Goodrich et al, 2007 www.pressthebuttons.com/

  10. How KO’s were made Goodrich et al., 1997

  11. Heterozygous Mice Goodrich et at., 1997

  12. Heterozygous Mice Goodrich et at., 1997

  13. How does Ptc relate to cancer? • Gorlin Syndrome • Basal Cell Carcinomas • Medulloblastomas • Sporadic Instances • Ionizing Radiation http://www.medicalecology.org/images/atmosphere/skincancer1.gif

  14. How does Ptc relate to cancer? • Meningiomas, Breast and Esophageal carcinomas • Shh/Ptc pathway hyperactive in many other cancers

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