Transforming Growth Factor β in Systemic Sclerosis

Jul 03, 2025

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This paper discusses the central role of Integrin-mediated activation of TGF-β in systemic sclerosis based on a study by Lafyatis, R. (2014). It explores the implications of TGF-β signaling in the disease pathogenesis and progression.

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Transforming Growth Factor β in Systemic Sclerosis

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Figure 3 Integrin-mediated activation of TGF‑β Lafyatis, R. (2014) Transforming growth factor β—at the centre of systemic sclerosis Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2014.137

Clues to Understanding the Innate Immune Response

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Chemiosmotic Theory of ATP Production

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Figure 3 Endothelial cell activation by anti‑β 2 GPI autoantibodies

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Created by

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Figure S1

Figure S1. Figure S2 (a). Figure S2 (b). Figure S2 (c). Figure S2 (d). Figure S2 (e). Figure S2 (f). Figure S2 (g). Figure S2 (h). (b). (a). (c). Figure S3. Figure S4. Figure S5 (a). Figure S5 (b). Additional Figure Legends Figure S1. Pre-computed annotation tracks in Rice-Map.

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Microvascular inflammation and endothelial cell activation in kidney antibody mediated rejection

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Figure S1.

Figure S1. a. b. Figure S1. Expression of gp91 phox and p22 phox subunits of flavocytochrome b and quantitative analysis of NADPH oxidase activity following SF71gp91 phox -mediated gene transfer

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07_CO.jpg

07_CO.jpg. Chapter Opening Figure. 07_01.jpg. Figure 7.1. 07_01a.jpg. Figure 7.1a. 07_01b.jpg. Figure 7.1b. 07_02a.jpg. Figure 7.2a. 07_02b.jpg. Figure 7.2b. 07_02c.jpg. Figure 7.2c. 07_03.jpg. Figure 7.3. 07_04.jpg. Figure 7.4. 07_04a.jpg. Figure 7.4a. 07_04b.jpg. Figure 7.4b.

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Effector mechanisms of humoral immunity

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Figure S4

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Figure 3 Transcriptional regulation mediated by PPARs and LXRs

Figure 3 Transcriptional regulation mediated by PPARs and LXRs. Choudhury RP et al . (2005) Mechanisms of Disease: macrophage-derived foam cells emerging as therapeutic targets in atherosclerosis Nat Clin Pract Cardiovasc Med 2: 309 – 315 doi:10.1038/ ncpcardio0195.

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GP1b-IX-V

PLATELET: 2 receptors for initial platelet adhesion and activation in flowing blood. N-terminal GP1 α: major binding region for: vWF leukocyte integrin aM  2 (Mac-1) -thrombin P-selectin (activated endotelium and platelet). 2 GP1 α 2 GP1  2 GPIX 1 GPV.

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α β

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Conclusions

Figure 4: Thermograms of the AC with different burn off prepared from PEEK by physical activation with CO 2 at 1173K. Figure 3: Thermograms off PEEK and PET polymers. Figure 1: N 2 adsorption isotherms on AC prepared at 1173K for different activation times.

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The Integrated Activation Solution

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GP1b-IX-V

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Molecules involved in T cell activation

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Tolerance, autoimmunity and the pathogenesis of immune-mediated inflammatory diseases

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Figure 1. Omron HJ-720 ITC enhanced pedometer.

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