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This study aims to assess the efficacy of various treatment approaches for drug-addicted pregnant women, including medication, behavioral modifications, and random assignment interventions. The goal is to identify the most effective method for improving outcomes and ensuring the health of both the mother and the baby.
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Oslin ExTENd Naltrexone 8 wks Response Randomassignment: TDM + Naltrexone Early Trigger for Nonresponse CBI Randomassignment: Nonresponse CBI +Naltrexone Randomassignment: Naltrexone 8 wks Response Randomassignment: TDM + Naltrexone Late Trigger for Nonresponse Randomassignment: CBI Nonresponse CBI +Naltrexone
Pellman ADHD Study A1. Continue, reassess monthly; randomize if deteriorate Yes 8 weeks A. Begin low-intensity behavior modification A2. Add medication;bemod remains stable butmedication dose may vary Assess- Adequate response? Randomassignment: No A3. Increase intensity of bemod with adaptive modifi-cations based on impairment Randomassignment: B1. Continue, reassess monthly; randomize if deteriorate Yes 8 weeks B2. Increase dose of medication with monthly changes as needed B. Begin low dose medication Assess- Adequate response? Randomassignment: B3. Add behavioral treatment; medication dose remains stable but intensityof bemod may increase with adaptive modificationsbased on impairment No
Proposed Study for Drug-Addicted Pregnant Women rRBT 2 wks Response Randomassignment: tRBT tRBT tRBT Randomassignment: Nonresponse eRBT Randomassignment: aRBT 2 wks Response Randomassignment: rRBT rRBT Randomassignment: tRBT Nonresponse rRBT