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ESM technology: enhancing drug performance

ESM technology: enhancing drug performance. Neutral molecules pass freely through cell. Pharmacokinetics limited by clearance from plasma. Intracellular target. “Parent” molecule. ESM technology: enhancing drug performance. Linking motif to parent creates novel IP.

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ESM technology: enhancing drug performance

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  1. ESM technology: enhancing drug performance • Neutral molecules • pass freely through cell • Pharmacokinetics • limited by clearance • from plasma Intracellular target “Parent” molecule

  2. ESM technology: enhancing drug performance • Linking motif to parent • creates novel IP • Neutral parent/motif is • cell permeable Intracellular target

  3. Family of three • enzymes • Expression of • one is restricted • to macrophages ESM technology: enhancing drug performance • Linking motif to parent • creates novel IP • Neutral parent/motif is • cell permeable • Motif cleaved by • intracellular enzyme • leaving charged species ± Intracellular target • Charged species also • novel/patentable • Charged species • accumulates in cell

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