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L7. L4. TB7. TB4. TB7. L7. TB4. L4. Regulation of Genes Relevant to General Immune Response C6 Complement component 6, facilitates clearance of antigen-antibody complexes C1R Complement component 1r, facilitates clearance of antigen-antibody complexes

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L4

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  1. L7 L4 TB7 TB4 TB7 L7 TB4 L4 Regulation of Genes Relevant to General Immune Response C6 Complement component 6, facilitates clearance of antigen-antibody complexes C1R Complement component 1r, facilitates clearance of antigen-antibody complexes CD59 Inhibitor of the membrane attack complex LTB4DH Catalyses conversion of leukotriene B4 into its less active metabolite C7 Complement component 7, facilitates clearance of antigen-antibody complexes C1R Complement component 1r, facilitates clearance of antigen-antibody complexes DAF Antagonist of the complement cascade C3AR1 Complement component 3a receptor 1 IL1RAP Essential for activation of interleukin 1-associated kinase MMP15 Tissue remodeling (reactivity and plasticity of lymphoid tissue) MMP25 Tissue remodeling (reactivity and plasticity of lymphoid tissue) PTX3 Acute phase reactant induced by interleukin 1beta in vascular endothelial cells Regulation of Genes Relevant to Interferon Pathways G1P3 Inducible by interferon alpha SP110 Inducible by interferon gamma IFIT1 Inducible by interferon alpha, IL1, retinoic acid, viral infection IFNGR1 Interferon gamma receptor 1 IFNGR1 Interferon gamma receptor 1 IFI16 Inducible by interferon gamma and later by interferon alpha IFI16 Inducible by interferon gamma and later by interferon alpha MNDA Responsive to interferon alpha IRF2 Represses interferon alpha/beta and interferon-induced MHC Class I JAK1 Janus kinase 1 (a protein tyrosine kinase) IFRD2 interferon-related developmental regulator 2 PKR Homo sapiens double stranded RNA activated protein kinase (PKR) gene, intron 4 IFNAR Receptor for interferon alpha/beta IFNAR2 Receptor for interferon alpha/beta/omega CCL11 Responsive to interferon gamma, IL1, TNFalpha CCL11 Responsive to interferon gamma, IL1, TNFalpha MX1 Myxovirus (influenza virus) resistance 1, inducible by interferons alpha, beta, gamma IFNG interferon, gamma IFITM1 Inducible by interferon alpha and gamma IFITM1 Inducible by interferon alpha and gamma IL13 Downregulates interferon gamma IRF7 Induces interferon alpha IFITM2 Inducible by interferon alpha and gamma IFITM3 Inducible by interferon alpha and gamma

  2. TB4 TB7 L7 L4 Regulation of Genes Relevant to Immune Cell Migration DPT Adhesion protein expressed in connective tissue DPT Adhesion protein expressed in connective tissue ITGBL1 Integrin, beta-like 1 ITGA2B Integrin, alpha 2b SDC2 Syndecan 2, heparin sulfate proteoglycan CXCL12 Attracts both T lymphocytes and monocytes CXCL12 Attracts both T lymphocytes and monocytes IL8 Attracts neutrophils and T cells CXCR6 Chemokine receptor present on activated T cells and lymphoid tissue IL8 Attracts neutrophils and T cells CCL3 Attracts neutrophils CD44 Plays a role in lymphocyte homing to lymph nodes ICAP-1A Recruit integrins β-1 to the focal contacts during cell adhesion CCL5 Chemoattractant for T helper cells and monocytes CCL28 Chemoattractant for T helper cells and cytotoxic T cells ITGB1 Beta 1 integrin isoform CD47 Transduces signals from integrins, facilitates neutrophil migration & activation ITGAL Integrin, alpha L PECAM-1 Cell adhesion molecule on endothelial cells, monocytes, neutrophils, & certain T cells AOC3 Adhesion protein on high endothelial venules of lymph nodes, chemoattractants for T cells SELE Selectin E (endothelial adhesion molecule 1) CCL11 Chemokine induced by interleukin 1, TNF α, and interferon γ CCL11 Chemokine induced by interleukin 1, TNF α, and interferon γ ITGB3BP Integrin beta 3 binding protein CXCL11 Chemoattractant for activated T cells CMKBR3 Chemokine receptor for T helper 2 cells CXCR3 Chemokine receptor for interferon-inducible proteins ICAM2 Lymphocyte recirculation from lymph nodes and MK cell-mediated clearance Regulation of Genes Relevant to Antigen Presentation on MHC Complexes HSPA2 Heat shock protein A2, may play a role in processing of MHC Class I complexes HLA-DOB Major histocompatibility complex, class II, DO beta HLA-A Major histocompatibility complex, class I, A HLA-C Major histocompatibility complex, class I, C HERPUD1 ER stress-inducible, ubiquitin-like domain member 1 PSMA1 Proteasome subunit involved in antigen processing for presentation CALR Calreticulin, heat shock protein important in processing MHC Class I complexes HSP89-alpha Heat shock protein 89-alpha, may be involved in processing of MHC Class I complexes SERPINH1 Heat shock protein 47, may be involved in processing of MHC Class I complexes IFNAR Stimulation during type I INF response causes MHC Class I induction in infected cells IFNAR2 Stimulation during type I IFN response causes MHC Class I induction in infected cells HSPA9B heat shock 70kDa protein 9B (mortalin-2) TRAP1 Heat shock protein 75 HLA-DQA1 Major histocompatibility complex, class II, DQ alpha 1 TB7 TB4 L4 L7 Regulation of Genes Relevant to Neutrophil Function EBI2 Expressed in pro-myelocytic cell lines IL2RB Mediates Induction of stem cells into myeloid development IL8 Attracts and activates neutrophils IL8 Attracts and activates neutrophils CCL3 Chemotactic factor for neutrophils AOAH Phagocytosis by neutrophils C3AR1 Stimulates granule release and superoxide production CSF2RB Receptor for stimulation factor of granulocytes MNDA Stimulation of myeloid cells CD47 Facilitates neutrophil migration and activation ITGAL Antibody-dependent neutrophil killing PECAM-1 Cell adhesion molecule present on neutrophils TNFSF14 Expressed in granulocytes and mediating T cell proliferation MMP2 Facilitates egress of neutrophils from lung parenchyma to airways MMP9 Present in neutrophils IL3 Growth stimulation factor of granulocytes c-fms Upregulated in stem cells induced into myeloid development IL2RA Mediates induction of stem cells into myeloid development MMP7 Facilitates egress of neutrophils from lung parenchyma to airways MMP7 Facilitates egress of neutrophils from lung parenchyma to airways

  3. L7 TB7 L4 TB4 TB7 L7 TB4 L4 Regulation of Genes Relevant to Monocyte/Macrophage Function CES1 Detoxifying enzyme specific to alveolar macrophages CXCL12 Attracts monocytes CXCL12 Attracts monocytes EBI2 Expressed in pro-myelocytic cell lines IL2RB Mediates in induction of stem cells into myeloid development IL15 Produced by monocytes TNFSF5 Expressed on macrophages, mediates cytokine production CSF2RB Receptor for stimulation factor of macrophages MNDA Stimulation of myeloid cells PDE4B Involved in signal transduction in monocytes CD80 Expression on B cells is induced by secretion of ICAM1 by macrophages CD84 Expressed by monocytes CCL5 Chemoattractant for monocytes ITGAL Antibody-dependent macrophage killing PECAM-1 Cell adhesion molecule present on monocytes TNFSF14 Expressed in monocytes and mediating T cell proliferation LILRB1 Expressed on monocytes MMP2 Facilitates egress of macrophages from lung parenchyma to airways MMP9 Present in alveolar macrophages IFNG Secreted by macrophages LILRB2 Expressed on monocytes IL3 Growth stimulation factor of macrophages c-fms Upregulated in stem cells induced into myeloid development IL2RA Mediates in induction of stem cells into myeloid development MRC1 Macrophage mannose receptor TGFB3 Expressed in macrophages Regulation of Genes Relevant to NK cell Function GZMA Cytotoxicity GZMA Cytotoxicity GZMB Cytotoxicity TNFRSF6 Involved in cytotoxic functions of NK cells IL15 Induces differentiation of NK cells KLRC1 Inhibitory lectin-like receptor present on NK cells KIR3DL2 Inhibitory killer immunoglobulin-like receptor present on NK cells TNFSF6 Involved in cytotoxic functions of NK cells KLRC4 Inhibitory lectin-like receptor present on NK cells KLRC3 Inhibitory lectin-like receptor present on NK cells KLRD1 Inhibitory lectin-like receptor present on NK cells KIR2DL3 Inhibitory killer immunoglobulin-like receptor present on NK cells NKG2-D Inhibitory lectin-like receptor present on NK cells IL5RA Binds IL5 secreted by NK cells JAK3 Tyrosine kinase expressed by NK cells LILRB1 Inhibitory immunoglobulin-like receptor present on NK cells IFNG interferon, gamma, produced by NK cells LILRB2 Inhibitory immunoglobulin-like receptor present on NK cells ICAM2 Plays a role in NK cell-mediated clearance Regulation of Genes Relevant to Dendritic Cell Function TNFSF11 Augments the ability of dendritic cells to stimulate naïve T cells to proliferate CD80 Expressed by dendritic cells LY75 Antigen uptake receptor on dendritic cells LILRB1 Inhibitory immunoglobulin-like receptor present on dendritic cells LILRB2 Inhibitory immunoglobulin-like receptor present on dendritic cells

  4. L7 TB7 TB4 L4 Regulation of Genes Relevant to T cell Function GZMA Cytotoxicity GZMA Cytotoxicity GZMB Cytotoxicity CXCL12 Attracts T cells TNFSF11 Stimulation of naïve T cells to proliferate CXCL12 Attracts T cells TNFRSF6 Apoptosis of non-activated T cells and Tc cell-mediated apoptosis IL2RB Mediates activation of T cells, and required for IL15-induced T cell proliferation LNK Adaptor protein between the T cell receptor and proteins participating in T cell activation IL15 Induces proliferation of T cells KLRC1 Inhibitory killer immunoglobulin-like receptor present on Tc cells IL8 Chemoattractant for T cells TNFSF5 Expressed on T cells and implicated in inflammatory cytokine production KIR3DL2 Inhibitory killer immunoglobulin-like receptor present on Tc cells IL8 Chemoattractant for T cells TNFSF6 Apoptosis of non-activated T cells and Tc cell-mediated apoptosis LAK lymphocyte alpha-kinase, participates in the T cell activation pathway KLRC4 Inhibitory lectin-like receptor present on Tc cells IFI16 Induced by interferon in lymphocyte, acts as a transcriptional repressor IFI16 Induced by interferon in lymphocyte, acts as a transcriptional repressor TNFSF4 OX40L induced on antigen-presenting cells after interaction with T cells IL1RAP Chemoattractant and pro-inflammatory for T cells KLRC3 Inhibitory lectin-like receptor present on Tc cells KLRD1 Inhibitory lectin-like receptor present on Tc cells KIR2DL3 Inhibitory killer immunoglobulin-like receptor present on Tc cells CD7 Marker of T cells CD80 T lymphocyte stimulation, proliferation, cytokine production, interacts with CD28 or CTLA4 CD84 Adhesion interactions between T cells and other cells TNFSF7 lymphocyte activation, proliferation, and generation of Tc cells CD44 Lymphocyte homing to lymph nodes JAK1 Involved in lymphocyte activation, cell cytotoxicity, and apoptosis CCL5 Chemoattractant for T helper cells FASTK Mediates apoptosis of mature T cells through caspase pathways and cytotoxicity FASTK Mediates apoptosis of mature T cells through caspase pathways and cytotoxicity CCL28 Chemoattractant for T helper cells and cytotoxic T cells ITGB1 Involved in lymphocyte activation and cytotoxicity IFNAR Involved in T cell survival & in enhancement of production of interferon gamma by T cells IL5RA Binds IL5 secreted by Tc and T helper cells to differentiate B cells to produce antibodies ITGAL Lymphocyte activation, cytotoxicity, apoptosis, recirculation of lymphocytes from LN JAK3 Functional competence of mature Tc cells TNFSF14 Stimulates proliferation of T cells IFNAR2 Involved in T cell survival & in enhancement of production of interferon gamma by T cells AOC3 Chemoattractant for T cells, recirculation of immune cells CXCL11 Chemoattractant for activated T lymphocytes IFNG Produced by Tc cells CMKBR3 Expressed in T helper 2 cells which activate B cells to produce antibodies IL2RA Mediates activation of T cells, and required for IL15-induced T cell proliferation ICAM2 Lymphocyte recirculation from lymph nodes

  5. Regulation of Genes Relevant to B Cell Function EBI2 Mediator of lymphocytic functions IL2RB interleukin 2 receptor, beta, present on B cells KLRC1 killer cell lectin-like receptor subfamily C, member 1 TNFSF5 tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome) KIR3DL2 Inhibitory killer immunoglobulin-like receptor present on B cells KIR3DL2 Inhibitory killer immunoglobulin-like receptor present on B cells KLRC3 Inhibitory lectin-like receptor present on B cells PDE4B Involved in signal transduction in B cells KLRD1 Inhibitory lectin-like receptor present on B cells KIR2DL3 Inhibitory killer immunoglobulin-like receptor present on B cells CD80 B cell stimulation, interacts with CD28 or CTLA4 on T cells CD84 On B cells, interacts with T cells NFKB1 Nuclear transcription factor of the kappa light chain in B cells IL5RA B cell receptor, differentiation of B cells into antibody-producing cells JAK3 Tyrosine kinase, plays a role in B cell development LILRB1 Inhibitory immunoglobulin-like receptor present on B cells TCF3 Facilitates transcription of immunoglobulin in B cells PTPN7 Stress-induced protein tyrosine kinase acting as a tumor suppressor in pre-B cells IL2RA interleukin 2 receptor, alpha, present on B cells TNFRSF17 B cell maturation factor, which promotes B cell survival L7 TB7 TB4 L4

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