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NeuroLOG and NeurIST: Advancing Computational Neuroscience Through Collaborative Projects

This workshop focuses on the NeuroLOG and NeurIST projects aimed at tackling major challenges in computational neuroscience. It addresses population aging, brain disorders, and the need for advanced data analysis techniques in medical imaging. With a budget of approximately 1M€ for NeuroLOG and 18M€ for NeurIST, the projects involve collaborative efforts from various academic partners and companies. Attendees will discuss semantic modeling, application deployment, and frameworks for integrating heterogeneous data to improve decision-making and treatment processes for neurological conditions, especially brain aneurysms.

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NeuroLOG and NeurIST: Advancing Computational Neuroscience Through Collaborative Projects

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  1. Joint @NeurIST - NeuroLOG workshopIntroduction C. Barillot May 18, 2010

  2. Projects Motivations • NeuroLog • Computational science & major challenge for this century • population aging • brain disorders growth • brain function understanding • … • Data intensive: • medical image databases, • statistical studies • Heterogeneous, semi-structured, sensitive data sets. • Complex data analysis procedures. • Compute intensive. • @NeurIST • To understand from the biomechanical point of view • aneurysm genesis • aneurysm growth • aneurysm rupture • To assess the • risk of aneurysm rupture • risk of aneurysm treatment • To select, when required, the best treatment for each patient, preventing aneurysm growth and rupture • Coiling • Coiling and stent • Flow diverters

  3. Applications • NeuroLOG • Multiple sclerosis • Early diagnosis • Evolution prediction • Brain stroke • Lesions volume variations • anatomo-functional relation • Dementia • Commonalities • Data sets: MR modalities, brain anatomy & functions • Processings & procedures: Registration, normalization, skull stripping, tissues classification. • @NeurIST • Brainaneurisms • Data: • Genomics • Imaging (MRI, CTA, 3D DSA) • Clinics • Biomechanics

  4. Shared issues • Connect to Brain Image Data Bases • Integration of heterogeneous and distributed data • Semantic mediation • Ontology for information modeling • Image processing workflow • Grid invocation • Derived Data Bases

  5. NeuroLOG Software architecture

  6. @NeurIST infrastructure @neuRisk  Improve decision making processes @neuEndo  Computational design processes to treat ruptured aneurysms Support Tools @neurIST Systems @neuLink  knowledge discovery for linking genetics to disease, @neuFuse  integration of modeling, simulation and visualization of multimodal data Enabling IT @neuCompute/Info  integration of data and computing resources

  7. @neurIST Architecture & Middleware • Architectural Overview • Service-Oriented Architecture • Compute & Data Services • Grid & Web Services • Grid Middleware • Decoupling of application suites from resources • On-demand computing • Data mediation • Semantic technologies

  8. Projects Numbers • NeuroLOG • Project Duration: 45m • Budget: ~1M€ • #teams involved: 9 • #people involved: ~30 • @NeurIST • Project Duration: 51m • Budget: ~18M€ • #teams involved: 30 • #people involved: 200+

  9. NeuroLOG Partners • 7 academic partners • I3S, IRISA, GIN, MIS, IFR49, INRIA Sophia, LRI • 2 companies - SAP, Visioscopie • Collaborating hosiptals • Pitié Salpétrière (Paris) • Michalon (Grenoble) • CHU Rennes • Antoine Lacassagne (Nice) LARIA (U. Picardie/CNRS) Amiens Paris Rennes LRI (Paris XI/CNRS) IFR 49 (INSERM) IRISA (INRIA/CNRS) Business Objects IRISA (INRIA/CNRS) INSERM U836 Grenoble Visioscopie Nice - Sophia Antipolis I3S UNSA/CNRS software technologies INRIA Sophia databases and knowledge medical imaging

  10. @neurIST Consortium

  11. Workshop Program • Objective of the day: • Introduce both projects • Identify common interests • Share experience • Compare adopted approaches • 13:30 Semantic Modeling of data • Neurolog: B. Gibaud, G. Kassel (15') • @Neurist: Jesús Bisbal, Martin Boeker (20') • discussion (25') • 14:30 Suites and clients • Neurolog: A. Gaignard, J. Montagnat (15') • @Neurist C. Ebeling ? (15') • discussion (30') • 15:30 Applications • Neurolog: M. Dojat (15') • @neurist: Christian Ebeling (15') • discussion (30') • 16:30 Discussions and wrap up • 17:30 Meeting closed • 10:00 Introduction (C. Barillot) • 10:20 Summary of the projects and overall set up of the platform • Neurolog: J. Montagnat (20') • @Neurist: Gerhard Engelbrecht (20') • 11:00 Databases mediation • Neurolog: F. Michel (15') • @Neurist: C. Ebeling, S. Benkner (30') • discussion (30') • 12:15 Lunch

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