Chapter 9.1 – Overview of the Excretory System

1. Chapter 9.1 – Overview of the Excretory System Pages 306 - 310

2. Structures of the Excretory System

4. The volume of blood entering the kidney through the renal artery in one day is more than the volume leaving through the renal vein. What does this tell you about where urine comes from? • Study the arrangement of the collecting ducts in relation to the renal pelvis. What does this indicate about the function of the renal pelvis?

6. 4. Identify where useful molecules and wastes are filtered out of the blood and into the nephron. • 5. Where are useful molecules reabsorbed from the nephron back into the blood? • 6. Describe the function of the excretory system. Overview of the excretory system

7. Chapter 9.2 – Urine Formation and the Nephrom Pages 311 - 315

8. Urine Formation • Four processes crucial to urine formation: • Glomerular filtration - moves filtrate (water and solutes) from blood into nephron. • Tubular reabsorption – removes useful solutes from filtrate back into blood for reuse by body systems. • Tubular secretion – moves additional wastes and substances from blood into filtrate. • Water reabsorption – returns water from the filtrate back to blood for reuse. Urine Formation

10. Glomerular Filtration • Start of urine formation, glomerular filtration: • Water and dissolved substances are forced from the blood in the glomerulus into the Bowman’s capsule • Capillaries of the glomerulus are very porous and allow water and dissolved solutes to easily pass through • Pores are small enough that blood cells and proteins cannot cross • High pressure in the glomerulus (4x higher than elsewhere), aides filtration

11. Tubular Reabsorption • Tubular reabsorption – the recovery process • Occurs in the loop of Henle • 65% of filtrate is reabsorbed to the body • Reabsorption occurs via active and passive transport • Nutrients like sodium, glucose and other solutes are actively transported back into blood from filtrate. • Negatively charged ions are passively absorbed by electrical attraction • Water is absorbed by osmosis

13. Tubular Secretion • Occurs in distal tubule and collecting duct • Excess hydrogen ions (H+) are secreted into the distal tubule to maintain the pH of the blood • Other substances not normally in the blood, such as medication, are secreted into the distal tubule filtrate • Reabsorption and secretion in the distal tubule are under the control of hormones (chapter 9.3)

15. Water Reabsorption • Water reabsorption occurs in the collecting duct • Filtrate still contains a lot of water • The reabsorption of water in the collecting duct causes the filtrate to become 4x as concentrated by the time it exits the duct. • The end product is approx. 1% of the volume of the original filtrate and is now called urine

16. Summary

17. Chapter 9.3 – Maintaining the Excretory System Pages 316 - 325

18. Water Balance • The solute concentration of blood remains constant despite variations in the amount of water we consume: • If water intake is too high the kidneys allow morewater to pass into the urine • If water is scare, the kidneys conserve water by producing concentrated urine

19. Osmotic Pressure • Osmotic pressure is the force generated by water as it moves via osmosis • The greater the concentration gradient the higher the osmotic pressure • Osmotic pressure affects many cellular activities, especially the exchange of matter between cells and blood. • Blood volume influences blood pressure, affecting the health of your cardiovascular system

20. Regulating the Reabsorption of Water • The hypothalamus regulates mechanisms maintain homeostasis: • Osmoreceptors in the hypothalamus measure osmotic pressure • When you are dehydrated, blood concentration increases and osmotic pressure increases • Hunger • Thirst • Blood pressure • Body temperature • Fluid balance • Salt balance

21. Osmotic receptors send a signal to the pituitary gland to release ADH (antidiuretic hormone)

22. ADH travels through the blood to the kidneys and increases the permeability of the distal tubule and collecting duct, allowing more water to be reabsorbed

23. If blood plasma is too dilute, osmotic pressure is low • Osmoreceptors stop or prevent the release of ADH • The distal tubules and collecting duct become less permeable to water; more water is excreted in the urine.

25. Reabsorption of Salts • A drop in blood Na+ concentration triggers a release of the hormone aldosterone • Aldosterone stimulates the distal tubules and collecting ducts to reabsorb Na+

26. Urine Analysis • Analyzing the physical and chemical composition of urine enables physicians to make inferences about an individual’s health

27. Disorders of the Excretory System • Common excretory system disorders: • Urinary tract infection (UTI) – due to bacterial or viral infection • Can affect the bladder or urethra • Characterized by urge to urinate, even when no urine is formed • Painful urination • Brown or bloody urine

28. Kidney Stones – due to crystalline formations in the kidney • Maybe caused by: recurrent UTIs, insufficient water consumption, low activity levels • Treatment may include ultrasound shock waves to break down stones to be passed via urethra; large stones may require surgery

29. Problems with Kidney Function • Nephrons can regenerate and restore kidney function after short-term injuries. • A person can survive on as little as 1/3 of onekidney. • If 75% or more of the nephrons are destroyed, urine output is inadequate to maintain homeostasis • Kidney function may be replaced by kidney transplant or through dialysis

30. Dialysis • Two types of dialysis: • Hemodialysis – artificial membrane in an external device acts as an artificial kidney • Peritoneal dialysis – utilizes the peritoneum (intestinal membrane) as the dialysis membrane.

31. Hemodialysis

32. Peritoneal Dialysis

33. Kidney Transplant • Dialysis is not intended to be a long-term treatment for kidney failure • Kidney transplant organs can come from cadaveric donors or from living donors • Individuals can function normally with one kidney • The success rate of kidney transplant is 90-95% with the aide of anti-rejection drugs Kidney Transplant Story