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Thibela ~ outstanding issues

Thibela ~ outstanding issues. Mixing between clusters Sampling strategy for final TB culture prevalence survey Availability of ART Statistical analysis plan ~ issues Database solution HIV prevalence. Mixing between/outside clusters. Measure of contamination across clusters

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Thibela ~ outstanding issues

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  1. Thibela ~ outstanding issues Mixing between clusters Sampling strategy for final TB culture prevalence survey Availability of ART Statistical analysis plan ~ issues Database solution HIV prevalence

  2. Mixing between/outside clusters Measure of contamination across clusters HR data to track workforce moving between clusters how to measure this? See statistical analysis plan Mixing outside clusters as low as 40% of the workforce live in hostels Patterns of leave more detailed data collection? qualitative, TB CNR at region, province? Mathematical modelling

  3. Sampling strategy for final TB culture prevalence survey A random sample of 750 employees per cluster culture from sputum specimen Cluster sizes range from 1000 to 10,000 Minimise the impact of this survey as a round of ACF measure TB case notification rates beyond the formal end of the study Sample proportional to cluster size

  4. Availability of ART Sample size factored in an effect of widespread use of ART (up to 30% reduction in TB incidence) Intervention and control clusters balanced for company Measure ART availability throughout the follow-up period 6 monthly draft questionnaire data required at the cluster-level Mathematical modelling

  5. Statistical analysis plan ~ issues start of measurement period end of the baseline survey restrict analysis to hostel dwellers probably not possible, not possible to identify hostel dwellers being reduced… contractors ~ TB

  6. Data management manage company downloads of HR data monthly downloads of the current workforce used for management of study and measuring outcomes databases for pilot studies develop data infrastructure for parent study: recruitment and follow-up of intervention clusters baseline and follow-up prevalence surveys TB episode data adverse events, urine testing for adherence, etc.

  7. Data management develop data infrastructure for parent study: large amount of data collection (one recruitment and 9 follow-up visits) electronic data capture at recruitment centre StudyBuilder 3 Data Managers

  8. HIV prevalence Measure of HIV prevalence at cluster level baseline survey, using blood important confounder refused permission by one Stakeholder Use of prevalence of HIV amongst TB cases as a surrogate? Cameroon study, Int JTuberc Lung Dis 2004 Brian Williams effect of ART? At baseline: TB case notification rate & radiological prevalence of TB Mathematical modelling

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