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Dioxin symposium 2010 San Antonio, TX, US 光学異性体に関する研究発表

Dioxin symposium 2010 San Antonio, TX, US 光学異性体に関する研究発表. 第１０回　ｅ - シンポジウム　 11.dec.2010 （大阪府環境農林水産総合研究所） 兵庫県環境研究センター 松村千里. C. l. C. l. C. l. C. l. C. l. C. l. C. l. C. l. C. l. C. l. C. l. C. l. C. l. C. l. C. l. C. l. C. l. C. l. C. l. C. l. C. l. C.

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Dioxin symposium 2010 San Antonio, TX, US 光学異性体に関する研究発表

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  1. Dioxin symposium 2010San Antonio, TX, US光学異性体に関する研究発表 第１０回　ｅ-シンポジウム　11.dec.2010 （大阪府環境農林水産総合研究所） 兵庫県環境研究センター 松村千里

  2. C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l 兵庫県でのこれまでの取り組んできた 光学異性体が存在するPOPs化合物 component-U82 heptachlor component-MC4 component-MC5 trans-chlordane cis-chlordane component-MC7

  3. C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C * C * C l C l H H C l C l C l C l C l C l C l C l C l C l C l C l C l C l H H C l C l C l C l C l C l C l C l C l C l C * C * O O C l H C l H C l C l C l C l C l C l C l C l H H C l C l C l C l C l C l C l C l C l C l O O H C l C l H C l C l C l C l C l H H C l H H H H C l C l H H C l H H C l H H C l C l C l C l C l C l H C l C l H C l C l C l C l O O C l C l C l C l H H H H 兵庫県でのこれまでの取り組んできた 光学異性体が存在するPOPs化合物 oxychlordene component-MC6 o,p’-DDT oxychlordane o,p’-DDD heptachlor-exo-epoxide PCBs ( 17 atropisomers ) alpha-HCH

  4. C l C l C l C l C l C l C l C l C l C l C l C l C l l C C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l C l Technical Chlordane trans-trans- cis- cis- MC-5MC-5 MC-4 MC-4 racemic MC-5 trans- cis- trans- MC-5 cis- MC-4 MC-4 Serum nonracemic

  5. 1332 THE SEA WATER CONCENTRATION AND ENANTIOMERIC FRACTION OF HCHs IN THE SEAS AROUND JAPAN Suzuki M1, Tsurukawa M1, Abe S2, Matsumura C1, Nakano T1, Kunugi M3 1Hyogo Prefectural Institute of Environmental Sciences, Yukihira-cho 3-1-27, Suma-ku, Kobe, Hyogo654-0037, Japan, 2Hyogo Environmental Advancement Association, Yukihira-cho 3-1-31, Suma-ku, Kobe, Hyogo 654-0037, Japan, 3Tokyo University of Science, 2641 Yamazaki, Noda-shi, Chiba 278-8510, Japan

  6. 1332 THE SEA WATER CONCENTRATION AND ENANTIOMERIC FRACTION OF HCHs IN THE SEAS AROUND JAPAN

  7. 光学異性体に関連する発表（Chiral、Enantiomer）光学異性体に関連する発表（Chiral、Enantiomer） POPs　（２題） 1407 PERSISTENT ORGANIC POLLUTANTS IN THE ARCTIC AND CANADA’S NORTHERN CONTAMINANTS PROGRAM (NCP) 1332 THE SEA WATER CONCENTRATION AND ENANTIOMERIC FRACTIONOF HCHs IN THE SEAS AROUND JAPAN HBCDs　（１２題） 1244 IS HEXABROMOCYCLODODECANE (HBCD) A GLOBAL POP? THE NORWEGIAN PROPOSALS TO INCLUDE HBCD IN UN CONVENTIONS ONPOPS 1267 EMERGING HALOGENATED FLAME RETARDANTS IN PEREGRINE FALCON (Falco peregrinus) EGGS FROM CANADA AND SPAIN. 1264 HEXABROMOCYCLODODECANE IN PEREGRINE FALCON (Falco peregrinus) EGGS FROM CANADA AND SPAIN: LEVELS AND ENANTIOMERIC PATTERNS. 1091 AN OVERVIEW OF CONTAMINATION OF THE UK ENVIRONMENT WITH HBCD AND ITS DEGRADATION PRODUCTS 1112 TIME COURSES OF HBCD LEVELS AND ENANTIOMERIC SIGNATURES IN HERRING GULL EGGS FROM THE GERMAN COAST 1033 LEVELS OF HBCDs AND DEGRADATION PRODUCTS IN UK HUMAN MILK ANDRELATIONSHIP TO EXTERNAL EXPOSURE 1195 HPLC BEHAVIOUR OF THE ISOMERS OF HEXABROMOCYCLODODECANE 1193 FURTHER MINOR ISOMERS OF HEXABROMOCYCLODODECANE 1113 HBCD ISOMERS: DEGRADATION RATES AND HYDROXYLATED PRODUCTS FROM MICROSOME INCUBATION EXPERIMENTS 1416 INVESTIGATION OF HBCD METABOLISM IN MARINE MAMMALS FROM CANADA USING A HEPATIC MICROSOMAL IN VITRO BIOASSAY APPROACH AND COMPARISON WITH FIELD SAMPLES 1409 IN VITRO METABOLISM OF HBCD ISOMERS BY RAT LIVER MICOSOMES 1436 METABOLISM OF α- AND γ-HEXABROMOCYCLODODECANE AND ENANTIOSELECTIVE FRACTIONS OF α-, β-, γ-ISOMERS IN MICE PFOS　（２題） 1460 ENANTIOSELECTIVE ANALYSIS OF A PFOS ISOMER: EVIDENCE FOR THE SOURCE CONTRIBUTION OF PRECURSORS TO AQUATIC ORGANISMS IN THE GREAT LAKES 1417 Isomer and enantiomer enrichment of perfluorooctane sulfonate (PFOS) in rats exposed to a PFOS-precursor Others　（５題） 1209 ATRAZINE AND METOLACHLOR IN ONTARIO SMALL LAKES and PRECIPITATION 1068 STUDY OF DISTRIBUTION PATTERNS AND CONCENTRATIONS OF SHORT CHAIN CHLORINATED PARAFFINS IN FARM SOILS IRRIGATED WITH WASTEWATER 1192 THE DRUG NAPROXEN AND ITS TRANSFORMATION PRODUCTS AS AN EXAMPLE FOR EMERGING ENVIRONMENTAL POLLUTANTS

  8. 1244 IS HEXABROMOCYCLODODECANE (HBCD) A GLOBAL POP? THE NORWEGIAN PROPOSALS TO INCLUDE HBCD IN UN CONVENTIONS ONPOPS Conclusion HBCD has passed the POP screening criteria of the Stockholm Convention4 and has been recognized as a POP under UNECE LRTAP5. As a next step of the process under the Stockholm Convention, a Risk Profile has been elaborated providing more detailed information on the use, the environmental fate and toxic properties of HBCD. This will be discussed at the next POPRC Meeting in October 2010. Under UNECE LRTAP, the review process to identify risk management measures for HBCD and potential exemptions, taking into account the lack of alternatives and socio-economic implications, has recently been completed. HBCD is now pending a final decision by the Executive Body on risk management measures and a possible listing of HBCD as a POP. Considering all the information available, it may be concluded that the production and use of HBCD presents a risk to the environment and health such that global action is warranted.

  9. ＨＢＣＤについて

  10. 1195 HPLC BEHAVIOUR OF THE ISOMERS OF HEXABROMOCYCLODODECANE Figure 1: Structural configurations of 10 HBCD isomers (adapted from Heeb et al.) (Dotted lines indicate meso forms; only one enantiomer is shown for the remaining isomers).

  11. 1195 HPLC BEHAVIOUR OF THE ISOMERS OF HEXABROMOCYCLODODECANE Figure 2: X-ray structures of 10 HBCD diastereomers grouped into shape families: A1) Square, A2) Quadrilateral, B1) Irregular (slight distortion), and B2) Irregular (major distortion).

  12. 1195 HPLC BEHAVIOUR OF THE ISOMERS OF HEXABROMOCYCLODODECANE Figure 3: Elution profile of selected HBCD isomers (“shape family” indicated in brackets).

  13. 1267EMERGING HALOGENATED FLAME RETARDANTS IN PEREGRINE FALCON (Falco peregrinus) EGGS FROM CANADA AND SPAIN.

  14. 1267EMERGING HALOGENATED FLAME RETARDANTS IN PEREGRINE FALCON (Falco peregrinus) EGGS FROM CANADA AND SPAIN.

  15. 1416INVESTIGATION OF HBCD METABOLISM IN MARINE MAMMALS FROM CANADA USING A HEPATIC MICROSOMAL IN VITRO BIOASSAY APPROACH AND COMPARISON WITH FIELD SAMPLES －ＨＢｒ －２（ＨＢｒ） －３（ＨＢｒ）

  16. 1264HEXABROMOCYCLODODECANE IN PEREGRINE FALCON (Falco peregrinus) EGGS FROM CANADA AND SPAIN: LEVELS AND ENANTIOMERIC PATTERNS.

  17. 1264HEXABROMOCYCLODODECANE IN PEREGRINE FALCON (Falco peregrinus) EGGS FROM CANADA AND SPAIN: LEVELS AND ENANTIOMERIC PATTERNS.

  18. 1091AN OVERVIEW OF CONTAMINATION OF THE UK ENVIRONMENT WITH HBCD AND ITS DEGRADATION PRODUCTS

  19. 1113HBCD ISOMERS: DEGRADATION RATES AND HYDROXYLATED PRODUCTS FROM MICROSOME INCUBATION EXPERIMENTS

  20. 1113HBCD ISOMERS: DEGRADATION RATES AND HYDROXYLATED PRODUCTS FROM MICROSOME INCUBATION EXPERIMENTS Figure 1: Progress of EF-values from a-, β-, and γ- HBCD racemates during an incubation period of 50 min. Each data point represents the average of two incubations (double injection) with the corresponding standard deviation.

  21. 1113HBCD ISOMERS: DEGRADATION RATES AND HYDROXYLATED PRODUCTS FROM MICROSOME INCUBATION EXPERIMENTS ＋OH体 Figure 2: HPLC-MS/MS-chromatograms of (-)α-HBCD (A) and of the resulting monohydroxy-HBCDs (B), formed by microsomal incubation.

  22. 1112TIME COURSES OF HBCD LEVELS AND ENANTIOMERIC SIGNATURES IN HERRING GULL EGGS FROM THE GERMAN COAST

  23. 1436METABOLISM OF α- AND γ-HEXABROMOCYCLODODECANE AND ENANTIOSELECTIVE FRACTIONS OF α-, β-, γ-ISOMERS IN MICE γ-[14C]HBCD dose was very rapid in that 59% of dose was excreted in the feces and 28% inurine within 4 days of dosing9

  24. 1436METABOLISM OF α- AND γ-HEXABROMOCYCLODODECANE AND ENANTIOSELECTIVE FRACTIONS OF α-, β-, γ-ISOMERS IN MICE

  25. 1033LEVELS OF HBCDs AND DEGRADATION PRODUCTS IN UK HUMAN MILK ANDRELATIONSHIP TO EXTERNAL EXPOSURE Table 1: Statistical summary of concentrations (ng g-1 lw) of target compounds and enantiomer fractions (EF) of HBCDs in the analysed human milk samples. ΣHBCDs ranged from 1 to 22 ng g-1 lw

  26. 1033LEVELS OF HBCDs AND DEGRADATION PRODUCTS IN UK HUMAN MILK ANDRELATIONSHIP TO EXTERNAL EXPOSURE Figure 1: LC-MS/MS chromatograms of (a) PBCDs and (b) TBCDs in human milk.

  27. 1033LEVELS OF HBCDs AND DEGRADATION PRODUCTS IN UK HUMAN MILK ANDRELATIONSHIP TO EXTERNAL EXPOSURE Table 2: Exposure (ng kg-1 bw day-1) of a 1 month old infant to the target BFRs via breast milk. Table 3: Estimated adult body burdens of HBCDs compared to observed levels in human milk.

  28. 1193 FURTHER MINOR ISOMERS OF HEXABROMO-CYCLODODECANE Figure 1: Structural configurations of 10 HBCD isomers (adapted from Heeb et al.). (Dotted lines indicate meso forms; only one enantiomer is shown for the remaining isomers)

  29. 1193 FURTHER MINOR ISOMERS OF HEXABROMOCYCLODODECANE Figure 2: Elution order of 10 HBCD isomers on a Restek Ultra II C18 column (1.8 μm, 2.1 x 50 mm) using a MeOH/ACN/water gradient.

  30. 1193 FURTHER MINOR ISOMERS OF HEXABROMOCYCLODODECANE Figure 3: Illustrating the influence of mobile phase composition on the elution order of the eta- and theta-HBCD isomers.

  31. 1209ATRAZINE AND METOLACHLOR IN ONTARIO SMALL LAKES and PRECIPITATION Kurt-Karakus, PB1, Muir, DCG1, Bidleman, TF2, Teixeira, C1, Small, J1 1 Science and Technology Branch, Environment Canada, 867 Lakeshore Road, Burlington, L7R 4A6, ON, Canada, Tel: +1 905 319-6921, Fax:+1 905 336-6430 2 Center for Atmospheric Research Experiments, Environment Canada, 6248 Eighth Line, Egbert, L0L 1N0, ON, Canada, Tel: +1 705 458-3322, Fax: +1 705 458-3301 1192 THE DRUG NAPROXEN AND ITS TRANSFORMATION PRODUCTS AS AN EXAMPLE FOR EMERGING ENVIRONMENTAL POLLUTANTS Hühnerfuss H1, Selke S1, Scheurell M1, Shah MR2, Nadeem S1,2 1University of Hamburg, Institute of Organic Chemistry, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany 2HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan 1091AN OVERVIEW OF CONTAMINATION OF THE UK ENVIRONMENT WITH HBCD AND ITS DEGRADATION PRODUCTS Harrad S1, Desborough J1, and Abdallah M A-E1,2 1Division of Environmental Health & Risk Management, School of Geography, Earth & Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK 2Department of Analytical Chemistry, Faculty of Pharmacy, Assiut University, 71526 Assiut, Egypt.

  32. 1267EMERGING HALOGENATED FLAME RETARDANTS IN PEREGRINE FALCON (Falco peregrinus) EGGS FROM CANADA AND SPAIN. Guerra P.1, Pacepavicius G.2, Jiménez B.3, Muñoz-Arnanz J3., Blázquez E.3, Fernie K.4, Champoux L.5, Marvin C.2, Macinnis G.2, Eljarrat E.1, Barceló D. 1,6 and Alaee M.2 1Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona, 18-26. 08034 Barcelona, Spain; 2Water Science and Technology, Environment Canada, 867 Lakeshore Road, Burlington Ontario, Canada, L7R 4A6; 3Department of Instrumental Analysis and Environmental Chemistry, Institute of Organic Chemistry, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain; 4Wildlife Toxicology and Disease, Environment Canada, 867 Lakeshore Road, Burlington, Ontario, Canada, L7R 4A6; 5Wildlife Toxicology and Disease, Environment Canada, 1141 Route de l'Église, Sainte-Foy, Quebec, Canada, G1V 4H5; 6Catalan Institute for Water Research (ICRA), Parc Científic i Tecnològic de la Universitat de Girona, Pic de Peguera 15, 17003 Girona, Spain. 1193 FURTHER MINOR ISOMERS OF HEXABROMOCYCLODODECANE McCrindle R1,2, Riddell N1, Chittim B1, McAlees A1 1Wellington Laboratories Inc., 345 Southgate Drive, Guelph, Ontario, Canada; 2University of Guelph, ChemistryDepartment, 50 Stone Road East, Guelph, Ontario, Canada

  33. 1460 ENANTIOSELECTIVE ANALYSIS OF A PFOS ISOMER: EVIDENCE FOR THE SOURCE CONTRIBUTION OF PRECURSORS TO AQUATIC ORGANISMS IN THE GREAT LAKES Brian J. Asher1, Yuan Wang2, Amila De Silva3, Sean Backus3, Derek Muir3, Charles S. Wong1,4, Jonathan W. Martin1,2 1Department of Chemistry, University of Alberta, Edmonton, AB, Canada 2Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada 3Water Science and Technology Directorate, Environment Canada, Burlington, ON, Canada 4Environmental Studies Program and Department of Chemistry, Richardson College for the Environment, University of Winnipeg, Winnipeg MB, Canada 1407PERSISTENT ORGANIC POLLUTANTS IN THE ARCTIC AND CANADA’S NORTHERN CONTAMINANTS PROGRAM (NCP) Kurt-Karakus, PB1, Muir, DCG1 1 Science and Technology Branch, Environment Canada, 867 Lakeshore Road, Burlington, L7R 4A6, ON, Canada, Tel: +1 905 319-6921, Fax: +1 905 336-6430 1113HBCD ISOMERS: DEGRADATION RATES AND HYDROXYLATED PRODUCTS FROM MICROSOME INCUBATION EXPERIMENTS Esslinger S, Becker R, Nehls I BAM Federal Institute for Materials Research and Testing, Richard-Willstätter-Straße 11, 12489 Berlin, Germany

  34. 1416INVESTIGATION OF HBCD METABOLISM IN MARINE MAMMALS FROM CANADA USING A HEPATIC MICROSOMAL IN VITRO BIOASSAY APPROACH AND COMPARISON WITH FIELD SAMPLES MacInnis GA1, Letcher RJ2, McKinney MA2, Tomy GT3, Lebeuf M3, Fång J4, Bergman Å4, Marvin CH1 1Environment Canada, Burlington, Ontario, Canada; 2Environment Canada, National Wildlife Research Centre, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario, Canada; 3Fisheries and Oceans Canada, Winnipeg, Manitoba and Mont-Joli, Quebec, Canada; 4Department of Chemistry, University of Stockholm, Stockholm, Sweden 1332 THE SEA WATER CONCENTRATION AND ENANTIOMERIC FRACTIONOF HCHs IN THE SEAS AROUND JAPAN Suzuki M1, Tsurukawa M1, Abe S2, Matsumura C1, Nakano T1, Kunugi M3 1Hyogo Prefectural Institute of Environmental Sciences, Yukihira-cho 3-1-27, Suma-ku, Kobe, Hyogo654-0037, Japan, 2Hyogo Environmental Advancement Association, Yukihira-cho 3-1-31, Suma-ku, Kobe, Hyogo 654-0037, Japan, 3Tokyo University of Science, 2641 Yamazaki, Noda-shi, Chiba 278-8510, Japan

  35. 1264HEXABROMOCYCLODODECANE IN PEREGRINE FALCON (Falco peregrinus) EGGS FROM CANADA AND SPAIN: LEVELS AND ENANTIOMERIC PATTERNS. Guerra P.1, Pacepavicius G.2, Jiménez B.3, Blázquez E.3, Fernie K.4, Champoux L.5, Marvin C.2, Macinnis G.2, Eljarrat E.1, Barceló D. 1,6 and Alaee M.2 1Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona, 18-26. 08034 Barcelona, Spain; 2Water Science and Technology, Environment Canada, 867 Lakeshore Road, Burlington Ontario, Canada, L7R 4A6; 3Department of Instrumental Analysis and Environmental Chemistry, Institute of Organic Chemistry, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain; 4Wildlife Toxicology and Disease, Environment Canada, 867 Lakeshore Road, Burlington, Ontario, Canada, L7R 4A6; 5Wildlife Toxicology and Disease, Environment Canada, 1141 Route de l'Église, Sainte-Foy, Quebec, Canada, G1V 4H5; 6Catalan Institute for Water Research (ICRA), Parc Científic i Tecnològic de la Universitat de Girona, Pic de Peguera 15, 17003 Girona, Spain. 1112TIME COURSES OF HBCD LEVELS AND ENANTIOMERIC SIGNATURES IN HERRING GULL EGGS FROM THE GERMAN COAST Esslinger Sa, Becker Ra, Jung Ca, Schröter-Kermani Cb, Nehls Ia a BAM Federal Institute for Materials Research and Testing, Richard-Willstätter-Strasse 11, D-12489 Berlin, Germany b UBA Federal Environment Agency, Corrensplatz 1, D-14195 Berlin, Germany

  36. 1409 IN VITRO METABOLISM OF HBCD ISOMERS BY RAT LIVER MICOSOMES Roosens Laurence1, Heather M. Stapleton2, Covaci Adrian1,3 1 - Toxicological Centre, Department of Pharmaceutical Sciences, Univ of Antwerp 2610 Wilrijk, Belgium 2 - Duke University, Nicholas School of the Environment, Durham, NC 3 - Laboratory for Ecophysiology, Biochemistry and Toxicology, Department of Biology, Univ of Antwerp2020 Antwerp, Belgium 1033LEVELS OF HBCDs AND DEGRADATION PRODUCTS IN UK HUMAN MILK ANDRELATIONSHIP TO EXTERNAL EXPOSURE Harrad1 S, and Abdallah M A-E1,2 1Division of Environmental Health and Risk Management, School of Geography, Earth and EnvironmentalSciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom. 2 Department of Analytical Chemistry, Faculty of Pharmacy, Assiut University, 71526 Assiut, Egypt. 1195 HPLC BEHAVIOUR OF THE ISOMERS OF HEXABROMOCYCLODODECANE Riddell N1, McCrindle R1,2, Chittim B1, McAlees A1 1Wellington Laboratories Inc., 345 Southgate Drive, Guelph, Ontario, Canada; 2University of Guelph, ChemistryDepartment, 50 Stone Road East, Guelph, Ontario, Canada

  37. 1244 IS HEXABROMOCYCLODODECANE (HBCD) A GLOBAL POP? THE NORWEGIAN PROPOSALS TO INCLUDE HBCD IN UN CONVENTIONS ONPOPS Becher G1, Tolfsen CC2, Säll L2 1 Division of Environmental Medicine, Norwegian Institute of Public Health, P.O.Box 4404 Nydalen, NO-0403Oslo, Norway 2 Section for Risk Assessment of Chemicals, Climate and Pollution Agency, PO Box 8100 Dep, NO-0032 Oslo,Norway 1436METABOLISM OF α- AND γ-HEXABROMOCYCLODODECANE AND ENANTIOSELECTIVE FRACTIONS OF α-, β-, γ-ISOMERS IN MICE Hakk H1, Huwe JK1, Szabo, DT2, Diliberto, JJ2, Birnbaum, LS3 1 USDA-ARS Biosciences Research Laboratory, 1605 Albrecht Boulevard, Fargo, ND 58102-2765 USA. 2US-EPA. ORD, NHEERL, 109 TW Alexander Dr., Research Triangle Park, NC 27711 USA, 3NIEHS & NCI, P.O. Box 12233, Research Triangle Park, NC 27709 1417 Isomer and enantiomer enrichment of perfluorooctane sulfonate (PFOS) in rats exposed to a PFOS-precursor Matthew S. Ross1, Yuan Wang3, Charles S. Wong1,2, Jonathan W. Martin1,3 1 University of Alberta, Department of Chemistry, Edmonton, Alberta T6G 2G2 Canada 2 Environmental Studies Program and Department of Chemistry, Richardson College for the Environment, University of Winnipeg, Winnipeg, MB, R3B 2E9 Canada 3 Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta T6G 2G3

  38. 1068 STUDY OF DISTRIBUTION PATTERNS AND CONCENTRATIONS OF SHORT CHAIN CHLORINATED PARAFFINS IN FARM SOILS IRRIGATED WITH WASTEWATER Lixi Zeng, Yawei Wang, Bo Yuan, Thanh Wang and Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, E-mail: gbjiang@rcees.ac.cn

  39. ＰＦＯＳ及びその他の化合物について

  40. 1417 Isomer and enantiomer enrichment of perfluorooctane sulfonate (PFOS) in rats exposed to a PFOS-precursor Figure 1. Isomer compositions of an electrochemically fluorinated (ECF) FOSA standard and in the blood of rats exposed to ECF FOSA for 99 days.

  41. 1417 Isomer and enantiomer enrichment of perfluorooctane sulfonate (PFOS) in rats exposed to a PFOS-precursor Figure 2. Percent enrichment of branched PFOS and FOSA in the blood of rats after 99 days of exposure to ECF FOSA. Percentages indicate the approximate percent of enrichment of branched isomers. Figure 3. Chromatograms demonstrating the separation of enantiomers of 1m-PFOS in standards (left, EF=0.512) and rat blood (right, EF=0.385).

  42. 1460 ENANTIOSELECTIVE ANALYSIS OF A PFOS ISOMER: EVIDENCE FOR THE SOURCE CONTRIBUTION OF PRECURSORS TO AQUATIC ORGANISMS IN THE GREAT LAKES

  43. 1460 ENANTIOSELECTIVE ANALYSIS OF A PFOS ISOMER: EVIDENCE FOR THE SOURCE CONTRIBUTION OF PRECURSORS TO AQUATIC ORGANISMS IN THE GREAT LAKES

  44. 1192 THE DRUG NAPROXEN AND ITS TRANSFORMATION PRODUCTS AS AN EXAMPLE FOR EMERGING ENVIRONMENTAL POLLUTANTS

  45. 1192 THE DRUG NAPROXEN AND ITS TRANSFORMATION PRODUCTS AS AN EXAMPLE FOR EMERGING ENVIRONMENTAL POLLUTANTS

  46. 1068 STUDY OF DISTRIBUTION PATTERNS AND CONCENTRATIONS OF SHORT CHAIN CHLORINATED PARAFFINS IN FARM SOILS IRRIGATED WITH WASTEWATER

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