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Structural Characteristics of RyR Ryanodine Receptor Channel Revealed by Samsó et al. (2005)

In a study by Samsó et al. (2005), the RyR Ryanodine Receptor channel is analyzed, highlighting features such as negative charges, size (10 Å long, 8 Å diameter), charge distribution (13 M of charge, 8 oxygens with charge -1/2), occupancy (18% of available volume), and crowding due to aspartate residues. This research provides valuable insights into the structural composition of RyR channels. Slide courtesy of Dirk Gillespie.

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Structural Characteristics of RyR Ryanodine Receptor Channel Revealed by Samsó et al. (2005)

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  1. Samsó et al., 2005 RyRRyanodine Receptor Slide from Dirk Gillespie, with thanks! • 4 negative charges • Cylinder 10 Å long, 8 Å diameter • 13 M of charge! • 8 oxygenswith charge -1/2 • 18% of available volume • Very Crowded! Aspartate

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