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LYMPHOMA

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  1. LYMPHOMA Malignant transformation of cell in Lymphatic system There are about 600 Lymph Nodes in the body Spleen and gut also have lymphatic tissue

  2. TYPES OF LYMPHOMAS • HODGKIN LYMPHOMA – LESS COMMON. MOSTLY OCCURS IN YOUNG ADULTS.6 SUBTYPES • NON-HODGKINS LYMPHOMA – USUUALLY SEEN AFTER 50. MANY SUBTYPES.

  3. CAUSES AND RISK FACTORS • VIRUSES • FAMILIAL/GENETIC • HIV • HERBICIDES/PESTICIDES

  4. SIGNS AND SYMPTOMS • PAINLESS SWELLING OF LN • FEVER • SWEATS AT NIGHT • ITCHING • PAIN IN LN AFTER TAKING ETOH

  5. DIAGNOSIS/STAGING • BIOPSY • BONE MARROW EXAM • CT/PET SCAN • BLOOD TESTS

  6. STAGES • STAGE I- SINGLE LN REGION • STAGE II- 2 OR 3 LN REGIONS • STAGE III- ABOVE AND BELOW DIAPHRAGM • STAGE IV- ORGAN INVOLVEMENT[LUNG,LIVER,BONE] • A AND B CATEGORIES

  7. TREATMENT • CHEMOTHERAPY –COMBINATION OF 3 TO 4 DRUGS . GIVEN OVER A PERIOD OF ABOUT 6 MONTHS • IMMUNOTHERAPY- MONOCLONAL ANTIBODIES • RADIOTHERAPY- CAN BE GIVEN ALONE OR WITH CHEMOTHERAPY • BONE MARROW TRANSPLANT

  8. CONLUSION • LYMPHOMAS ARE “GOOD” CANCERS • TREATMENT IS HIGHLY EFFECTIVE • CURE RATES FOR HODGKIN >90% • CURE FOR NHL ABOUT 60% OVERALL • BETTER TARGETED DRUGS IN PIPELINE

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