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New Oslo PSC Biobank: Comprehensive Biobanking for Clinical Research & Data Integration

The New Oslo PSC Biobank is a cutting-edge facility that centralizes clinical and research biobanking, utilizing broad consent to ensure comprehensive coverage for diverse biological materials and clinical data. It stores various samples including DNA, RNA, serum, plasma, and fresh tissues, all maintained under strict SOPs and regular quality control. Innovative barcode inventory and integrated databases enhance tracking and accessibility. This biobank supports epidemiological studies, disease-oriented research, and biomarker discovery in primary sclerosing cholangitis (PSC) and associated conditions.

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New Oslo PSC Biobank: Comprehensive Biobanking for Clinical Research & Data Integration

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  1. New Oslo PSC biobank

  2. New Oslo PSC biobank • Broadconsent – covers all clinical and researchbiobanking • Integratedstorage of clinical data and biological material • DNA, RNA (blood), serum, plasma, cell-isolates • Biliary eptihelialcells (brushings), bile, intestinalbiopsies • Freshtissue at liver explantation, cancer tissue at resection • Standardized and writtenprotocols all steps (SOP) • Regular QC of stored material • Barcode-basedinventory system (-80°C/liquid nitrogen)

  3. Physicalstorage system

  4. Physicalstorage system

  5. Database integration

  6. Biobanking - background Norsk senter for PSC

  7. Biobanks ? • Population banks • Biomarkers of susceptibility and population identity, and their operational substrate is germinal-line DNA from a huge number of healthy donors, representative of a concrete country/region or ethnic cohort • Disease-oriented banks for epidemiology • Biomarkers of exposure, using a huge number of samples, usually following a healthy exposed cohort/ case–control design studying germinal-line DNA or serum markers and a great amount of specifically designed and collected data. • Disease-oriented general biobanks (i.e. tumour banks) • Biomarkers of disease through prospective and/or retrospective collections of tumour and no-tumour samples and their derivates (DNA/RNA/ proteins), usually associated to clinical data and sometimes associated to clinical trials. • The amount of clinical data linked to the sample determinate the availability and biological value of the sample Norsk senter for PSC

  8. Biobanking in PSC – why and how ? • Ethiopatogenesis • Serum/plasma samples • DNA-samples • Liver biopsies/ explanted liver • Bile duct cytology/biopsies • Colon biopsies: IBD+/- • Disease progression • Liver biopsies • Bile duct cytology/biopsies • Cholangiocancer • Tumor material • Dysplasia cytology Norsk senter for PSC

  9. Biobanking in PSC: Discussion • Controversy: Competition vs. collaboration • Types of material? • Minimal level • Standardization (SOP) • study group website w/protocols? • Material exchange conditions • study group MTA ? • Study proposals • centers

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