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ALK pathway

Anaplastic lymphoma kinase (ALK) is an enzyme that is encoded by the ALK gene in humans. Discovered in 1994, it was first identified as a receptor tyrosine kinase in a chromosomal translocation associated with some anaplastic large cell lymphomas(ALCL), where ALK takes its name.<br>

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ALK pathway

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  1. ALK pathway Anaplastic lymphoma kinase (ALK) is an enzyme that is encoded by the ALK gene in humans. Discovered in 1994, it was first identified as a receptor tyrosine kinase in a chromosomal translocation associated lymphomas(ALCL), where ALK takes its name. ALK was described as a fusion partner, and almost 70~80% of ALK-positive ALCL express the NPM–ALK which is an amino-terminal fusion derived from the nucleophosmin (NPM) protein. with some anaplastic large cell NPM itself has multiple functions including the transport of pre-ribosomal particles and ribosome biogenesis, regulation of cell division, DNA repair, transcription and genomic stability, playing a postulated role as either an oncogene or a tumor suppressor depending on its level of expression. NPM-ALK would prove to be the first of many ALK fusion proteins to be described in a wide range of cancer types. In addition to NPM–ALK, other fusions involving ALK include TFG, TPM3 and TPM4, as well as non-nuclear ALK fusion chimeras ATIC, CLTCL1 and moesin. https://www.creative-diagnostics.com/alk-pathway.htm

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