Tumor Immunology Pathway

1. Tumor Immunology Pathway Tumor immunology refers to the relationship between immune function and tumor cells, which is crucial for our understanding of the mechanisms of both tumor rejection and tumor progression. The immunological mechanisms involved in cancer growth are highly complex, including tissue-resident and blood-derived cells. The human immune system mounts natural endogenous response to highly immunogenic tumor cells through a series of steps, including the presenting of tumor antigens to T cells via antigen-presenting cells (APCs), priming and activation of T cells in the lymph nodes, trafficking and infiltration of T cells into tumor beds, recognition of cancer cells by T cells, development of antigen-specific effector and memory T cells, and humoral immunity, allowing effector T cells and other endogenous immune cells, as well as tumor-effective antibodies to tumor to eliminate cancer cells. Cancer cells can alter the steady-state activity of all myeloid cells present in the tumor microenvironment by secreting factors such as interleukin (IL)-6 or granulocyte-macrophage colony-stimulating factor (GM-CSF), that induce the recruitment of immature myeloid cells to tumor cells, as well as cell proliferation. Find more: https://www.creative-diagnostics.com/tumor-immunology-pathway.htm