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Glycolytic Pathway and Mitochondrial Energy Production Overview

This overview details the intricate biochemical pathways of glucose metabolism, emphasizing the glycolytic pathway, the conversion of glucose to pyruvate, and the subsequent mitochondrial processes that yield ATP. Key intermediates include fructose-6-P, glycerol-3-P, and succinate, highlighting the role of NADH and FADH2 in energy production. The text explores glycolysis, citric acid cycle components, and ATP synthesis, showcasing the complex interplay of enzymes and substrates crucial for cellular respiration and metabolic energy efficiency.

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Glycolytic Pathway and Mitochondrial Energy Production Overview

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  1. glucose succinate B GLYCOSOME A glucose glucose ATP 1 ADP G L Y C O S O M E glucose 6-P succinate 2 + NAD 17 NADH fructose 6-P g l u c o s e ATP fumarate ATP 3 ADP 1 ADP fructose 1,6-P 2 16 4 g l u c o s e 6 - P L-malate 5 G-3-P DHAP 2 + AMP NADH NAD ATP 15 6 8 + PPi NADH Pi NAD f r u c t o s e 6 - P 1,3-BPGA Oxac Gly-3-P ATP 14 ATP ADP 3 18 ADP 9 ADP ATP CO pyruvate PEP 2 glycerol f r u c t o s e 1 , 6 P M I T O C H O N D R I O N 2 4 5 H O 1,3-BPGA G - 3 - P glycerol D H A P D H A P 2 ADP N A D H ADP ATP 7 P ATP i 6 8 1 3 + pyruvate PEP 3-PGA N A D 12 10,11 G l y - 3 - P G l y - 3 - P 1 , 3 - B P G A 1 O - ADP ADP MITOCHONDRION 2 2 9 7 ATP ATP g l y c e r o l 3 - P G A 20 19 acetate acetate pyruvate AcCoA + Succ Succ-CoA NAD CO NADH 2 ATP g l y c e r o l 26 3 - P G A Citr Oxac 1 0 AA OA 23,22,21 KG proline Glu Pro + NAD 24 Mal 2 - P G A 25 + NADH NAD NADH CO 2 1 1 Fum ATP Succ-CoA H O succinate 26 2 succinate P E P succinate fumarate ADP ADP ATP + O H O NAD NADH 2 2 O 2 1 2 ATP H O 2 - e - e II pyruvate - e AOX III I - e UQ - e IV - e C + + + H + H 27 H H Gly-3-P DHAP

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