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Rhombix Solutions for Automated Crystallization 2007 RAMC

Rhombix Solutions for Automated Crystallization 2007 RAMC. Rhombix Product Line – supporting the crystallization workflow. Rhombix Software Suite. Semi-automated imaging. Automated imaging and storage. MaX Workcell.

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Rhombix Solutions for Automated Crystallization 2007 RAMC

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  1. Rhombix Solutions for Automated Crystallization 2007 RAMC

  2. Rhombix Product Line – supporting the crystallization workflow Rhombix Software Suite Semi-automated imaging Automated imaging and storage MaX Workcell

  3. Result: Isolated “islands” of automation and data stores -- No data connection Instrument-Centric to Data-Centric Automation Nanodispenser Drop-making Liquid handler – Dispense screens into wells Xtallization Database Experiment design and analysis Imaging and Storage

  4. New Product New MaX Workcell Plate preparation

  5. MaX Workcell • Features & Benefits • All-inclusive product – pre-configured for quick installation • Seamless Workflow • Tube-to-plate transfer • Plate-to-plate transfer • Custom screen building (gradients, additives, etc) • Nano Drop placement • Sealing • Multiple experiment design and submission • Full set of SW tools incorporating experimental data and automation control • Small footprint

  6. Imaging Modes Brightfield • White LED light source • Eliminates heating of plates Darkfield • Changes the angle of incidence mitigating shadow regions associated with Brightfield • Assists visualization of crystals Polarization • True polarization • Variable angle transmitter and analyzer • Exploits birefringent property of crystals

  7. Brightfield Lighting and treatment options • Darkfield • Variable Angle Polarization • Extinction + 90° • Extinction + 45° • Extinction

  8. Imaging Features • Drop-finding • X-focus (extended depth of focus) • Others: autofocus, autoexposure, sharpening

  9. Experiment Design Results Analysis and Scoring Experiment Execution Data Mining Optimization Rhombix Software Suite – Supporting the Crystallization Workflow Protein Crystallization Software Packages • Reagent Manager • Screen Designer • Experiment Manager • Schedule Editor • Barcode Manager • Deck Manager • Experiment Launcher • Screen Monitor • Vision Monitor • Equipment Monitor • Visual Query Tool • Image Viewing and Annotation (Clarix) • Report Tool Knowledge • Visual Query Tool • Image Viewing and Annotation (Clarix) • Screen Designer

  10. Rhombix Software Fourteen Software Applications Built into an Cohesive Framework Spanning: Reagent Management to Data-Mining User-defined values

  11. interface for viewing and annotating images brings in information from database (e.g. well contents & drop details) provides feedback to imaging link to Screen Design for optimization screens link to data-mining link to scheduling Viewing and Annotation -- Clarix

  12. Report Tool • Report across users and experiments • Export to .xls, .pdf, HTML, xml formats • One means of data sharing between sites (export at one site, import at another site)

  13. Graphical data-mining SW for general queries and experiment optimization planning Links to Viewing application for display of image results Data Mining – Visual Query Tool

  14. Screen Designer • Graphical interface for designing screens • Allows concentration and pH gradients • Gradients across grids, rows, columns • Patterns of start/step, start/end, center/step

  15. Import Utility • Imports chemicals, screening solution formulations, screens, and experiments • Pair with report tool for data sharing

  16. More Insight and Less Mystery in Crystallization Tools for easy data retrieval and viewing Tools for easy data entry “Drop to Crystal” Workflow

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