Clinical and Translational Science Award Consortium Meeting October 3, 2007

1. National Center forResearch Resources A c c e l e r a t i n g a n d e n h a n c i n g r e s e a r c h f r o m b a s i c d i s c o v e r y t o i m p r o v e d p a t I e n t c a r e NATIONAL INSTITUTES OF HEALTH Clinical and Translational Science Award Consortium Meeting October 3, 2007 Barbara Alving, M.D. Director National Center for Research Resources

2. Building A National CTSA Consortium Case Western Reserve University University of Pittsburgh University of Michigan University of Washington University of Rochester WA ME MT ND Oregon Health & Science University MN OR VT WI NH Yale University Mayo Clinic College of Medicine NY ID MI Weill Cornell Medical College MA SD Columbia University University of Wisconsin WY Rockefeller University IA NJ University of Iowa University of California, Davis University of Pennsylvania PA NE NV University of Chicago Johns Hopkins University University of California, San Francisco IL IN Washington University, St. Louis OH UT WV CO VA KS MO CA KY Vanderbilt University Duke University TN AZ OK NM AR SC Emory University University of Texas Southwestern Medical Center GA AL MS LA TX AK University of Texas Health Science Center at Houston FL HI Participating Institutions Since 2006 Since 2007

3. NCRR: Focus on Clinical and Translational Research Biomedical Technology Comparative Medicine Clinical Research Research Infrastructure

4. Institutional Development AwardIncreasing research capacity in 23 underserved states and Puerto Rico Montana State U. WA ME ND U. ofIdaho MT VT MN OR NH ID MA WI NY SD CT RI WY MI NJ PA IA NE NV U. Wyoming MD OH DE U.Nevada Reno IN IL UT CO WV VA KS MO CA KY NC TN AZ OK AR SC NM U. Alaska GA AL MS TX LA AK FL HI PR U. Hawaii = Lariat Project: encircling institutions with connectivity = IDeA-Eligible States

5. = RCMIs = RCMI/RCMI Clinical Research Centers Research Centers in Minority Institutions 18 Centers in 10 States, the District of Columbia, and Puerto Rico City College CUNY Hunter College CUNY Morgan State Univ, MD Howard Univ, DC Meharry Medical College, TN Clark Atlanta Univ, GA Charles R. Drew Univ, CA Morehouse School of Medicine, GA Florida A&M Univ, FL Univ of Texas at El Paso, TX Univ of Puerto Rico, Medical Sciences Campus, PR Tuskegee Univ, AL Univ of Hawaii at Manoa, HI Jackson State Univ, MS Univ Central del Caribe, PR Univ of Texas at San Antonio, TX Ponce School of Medicine, PR Texas Southern Univ, TX

6. National Primate Research Centers Washington NPRC Oregon NPRC Harvard, New England NPRC Wisconsin NPRC UC Davis NPRC Emory University, Yerkes NPRC Southwest Foundation NPRC Tulane NPRC

7. Animal Model Resource Centers • Non-human Primates • National Primate Research Centers • Rodents • Genetically engineered mice and rodents • Aquatics • Zebrafish, sea slugs, squid, octopus • Comparative Models • Fruit fly, Worm, (c.elegans), swine, stem cells

8. WA ME MT ND VT NY MN OR NH MA WI ID SD MI WY RI PA CT IA NJ NE IN NV DE OH MD UT WV IL CO VA CA DC KS MO KY NC TN OK ` AR SC AZ NM AL MS GA LA TX FL AK HI Biomedical Technology Research Resources (BTRRs) Locations Users of BTRRs United States: 6,171Foreign: 793Total: 6,964

9. Imaging • MRI • Magnetic resonance spectroscopy • Image-guided therapy Informatics • Genetics • Modeling of complex systems • Molecular dynamics • Visualization • Imaging informatics Optics & Laser • Microscopy • Fluorescence spectroscopy • In Vivo diagnosis Structural Biology • Synchrotron x-ray technologies • Electron microscopy • NMR Systems Biology • Mass spectrometry • Proteomics • Glycomics & glycotechnology • Flow cytometry In studying the developing brain, approaches are being developed to distinguish development from change in size; disease from normal development; and to study special populations such as children and elderly. These technologies are currently being used in clinical research and may eventually be translated to clinical practice. Computational Biology will enable “P4” medicine (Personalized, Participatory, Predictive, Preventive). Personalized biomedical simulations, enabled by high performance computing at BTRRs, will lead to predictive and preventive personalized medicine. BTRRs are building spatially realistic models, integrating functionality among software and approaches, and integrating knowledge derived from disparate data sources. Many research and medical uses derived and commercialized since 1980: laser scissors, chromosome cutting, laser tweezers, tissue ablation, optical coherence tomography, multi-photon microscopy, ovarian and brain photodynamic therapy Essential technologies (both instrumentation and approaches) for structure-based drug design have been developed at NCRR BTRRS: e.g. x-ray crystallography, NMR, and computational modeling Accelerator Mass Spectrometry (AMS) is used to trace how the human body processes small amounts of toxins or nutrients, in amounts an individual might normally ingest from food. This approach may be used in “individualized medicine” to determine the ideal dose of medicine to give to an individual patient Biomedical Technology Research Resources 50 Centers in 5 Broad Areas

10. Provide funding for instrumentation in cost-range from $100K to $2.0M Equipment which is too costly to obtain with regular NIH research grants Instruments placed in core facilities Shared by an average of 8-10 grantees FY 2006 SIG funding: $43.9 million FY 2006 HEI funding: $21.5 million Examples of instrumentation: Biomedical Imagers Cell Sorters Confocal Microscopes Mass Spectrometers Shared Instrumentation Grant and High-End Instrumentation Program

11. Funding Comparison - Centers vs. RPGs 8% of Funding 92% of Funding • Center Grants = $760M • RPGs = $69M 93% of Funding 7% of Funding • Center Grants = $141M • RPGs = $2B