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Quantitative Trait Loci Analysis of HDL Cholesterol Across Inbred Mouse Strains

This study investigates the genetic basis of HDL-cholesterol concentrations and susceptibility to atherosclerosis using quantitative trait loci (QTL) analysis in inbred mouse strains C57BL/6J and 129S1/SvImJ. We analyzed 294 F2 progeny females on a high-fat diet to identify chromosomal regions associated with HDL levels and atherosclerosis risk. Our findings reveal six loci linked to HDL and five loci related to atherosclerosis susceptibility. Future studies will explore ways to enhance HDL levels through diet and exercise, emphasizing omega-3 fatty acids and other lifestyle changes.

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Quantitative Trait Loci Analysis of HDL Cholesterol Across Inbred Mouse Strains

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  1. No more broken hearts Presented by: Jeffrey Avila Janae Gonzales Burt Matthews Quantitative Trait Loci Analysis for Plasma HDL-Cholesterol Concentrations and Atherosclerosis Susceptibility Between Inbred Mouse Strains C57BL/6J and 129S1/SvImJ Arterioscler. Thromb. Vasc. Biol. 2004;24;161-166 Naoki Ishimoriet.al.

  2. QTL • What is it?

  3. QTL • What is it? • What does it tell us?

  4. QTL • What is it? • What does it tell us? • Why is it important?

  5. Overview of study • B6X129

  6. Overview of study • B6X129 • 294 F2 Progeny Females

  7. Overview of study • B6X129 • 294 F2 Progeny Females • High Fat Diet

  8. Overview of study • B6X129 • 294 F2 Progeny Females • High Fat Diet • Identify regions on chromosomes using QTL analysis

  9. Phenotypic Measurements

  10. QTL Analysis

  11. Relevance • 6 loci HDL + 5 Loci atherosclerosis suseptability identified • The Future • Lipoproteins • Medications

  12. Ways to increase my HDL levels • Exercise • Increase intake of Omega 3 fatty acids • Eat Onions

  13. A special thanks to…. • Randy Von Smith • Tobias Beckwith • Dr. Brook Milligan • NMSU RISE Program

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