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Improved Design for Fine-Needle Aspiration (FNA) of Breast Cancer Lesions

Improved Design for Fine-Needle Aspiration (FNA) of Breast Cancer Lesions . Alissa Garman Janie Goldsworthy Kristi Hinner Nick Kortan Client: Elizabeth Burnside Advisor: John Webster Final Presentation May 2, 2003. Problem Statement.

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Improved Design for Fine-Needle Aspiration (FNA) of Breast Cancer Lesions

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  1. Improved Design for Fine-Needle Aspiration (FNA) of Breast Cancer Lesions Alissa Garman Janie Goldsworthy Kristi Hinner Nick Kortan Client: Elizabeth Burnside Advisor: John Webster Final Presentation May 2, 2003

  2. Problem Statement GOAL:To modify the needle used during a Fine Needle Aspiration (FNA) procedure. The modification should not drastically change the FNA procedure and still increase the amount of tissue removed for cytological testing. It should also minimize the time (by collecting an adequate sample size on the first attempt) and discomfort caused to the patient during the procedure.

  3. What is FNA? • Technique used to extract cells; no incision needed • Several insertions are usually required to ensure an adequate sample size • Samples are sent to pathologist to be analyzed National Breast Cancer Center, http://www.NBCC.org

  4. When does FNA not work? • Approximately 15% of trials • Dense, fibrotic, lobular tissue masses can prevent sufficient sample from conventional technique • Drill bit design could be as a backup in such cases

  5. Fine Needle Aspiration (FNA) A.D.A.M., http://www.adam.com

  6. Product Design Specifications • Removes adequate number of cells for diagnosis. • Should not cause more discomfort than current FNA procedure. • Constrained to standard 20-25-gauge needle, client prefers 23-gauge.

  7. Current Prototype • Pre-manufactured drill bit • 6” length • Fits in 23 gauge needle

  8. Tissues Tested • Fixed cat tissues (previous semester) • Mammary • Lymph • Fat • Living Tissues (this semester) • Mouse cystic and solid tumors

  9. Testing Procedures • Old technique • No insert used • Performed multiple trials on all tissues • New technique • Introducer followed by drill bit • Performed multiple trials on all tissues

  10. Sample Quantification • Old technique • 15 % of trials resulted in either a mass of cells or a minimal quantity of cells • New technique • More dispersed cell sample • Similar number of cells on average • May be easier technique for novices • May be used as back-up to conventional technique

  11. Future Work • Further prototype development • Research into appropriate materials to be used (stainless steel, Co-Cr, Ti) • Develop protocol for quantifying testing • Test on freshly removed fibrotic (pancreatic) tissue • Human trials • Cytological evaluation • Journal publication

  12. Sample Slides Benign FNA Cell Sample

  13. Sample Slides Malignant FNA Cell Samples

  14. Drill Bit Size Comparison

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