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METABOLISME DES CORPS CÉTONIQUES

METABOLISME DES CORPS CÉTONIQUES. S.A HAMMA. INTRODUCTION 1. CH 3 —CO—CH 2 —COOH Acétoacétate CH 3 —CHOH—CH 2 —COOH β - Hyroxybutyrate CH 3 —CO—CH 3 Acétone. INTRODUCTION 2. Glucose.

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METABOLISME DES CORPS CÉTONIQUES

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  1. METABOLISME DES CORPS CÉTONIQUES S.A HAMMA

  2. INTRODUCTION 1 CH3—CO—CH2—COOH Acétoacétate • CH3—CHOH—CH2—COOH β-Hyroxybutyrate CH3—CO—CH3 Acétone

  3. INTRODUCTION 2 Glucose Acides gras Besoins énergétiques Corps cétoniques Origine lipidique Facilité d’emploi énergétique du glucose  Petites molécules hydrosolubles Diffusion facile

  4. MÈTABOLISME DES CORPS CÈTONIQUES CÈTOGENÈSE CÈTOLYSE Mitochondrie Corps cétoniques Corps cétoniques Acétyl-CoA Acétyl-CoA Acides gras Acides aminés cétoformateurs

  5. CÈTOGENÈSE 1 ß-cétoacétylthiolase

  6. CÈTOGENÈSE 2

  7. CÈTOGENÈSE 3

  8. CÈTOGENÈSE 4

  9. CÈTOLYSE 1

  10. CÈTOLYSE 2 CoA Thiokinaseacétoacétique Acétoacétyl-CoA synthase ß-Cétoacyl-CoA transférase ATP AMP+ 2Pi

  11. CÈTOLYSE 3 ß-Cétothiolase

  12. RÉGULATION DE LA CÉTOGENÈSE - Insuline - - OAA Acétyl-CoA

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