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Cell-Mediated Cytotoxicity

Cell-Mediated Cytotoxicity. Cytotoxic T-Lymphocytes Natural Killer Cells Antibody-Dependent, Cell-mediated Cytotoxicity Delayed-type Hypersensitivity. Folder Title: CellKill. Updated: November, 25, 2004. KillTitl.

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Cell-Mediated Cytotoxicity

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  1. Cell-Mediated Cytotoxicity Cytotoxic T-Lymphocytes Natural Killer Cells Antibody-Dependent, Cell-mediated Cytotoxicity Delayed-type Hypersensitivity Folder Title: CellKill Updated: November, 25, 2004 KillTitl

  2. Cell-Mediated Immunity (CMI):Passive transfer from donor to recipient of cells alone, transfers the immune response function Response to: Neoplastic (cancer) Cells Infected or Altered Cells Intra-cellular Pathogens Fungi Allo-grafts and other transplants CMIRoles

  3. Cell-Mediated Immunity (CMI):Types of Cytotoxic Cells Antigen-Specific T-Cells (Have TCR): Tc : Cytotoxic T-Cells TDTH : Delayed-Type Hypersensitivity Cells ("Type IV Hypersensitivity") Non-Antigen-Specific Cells: Macrophages NK Cells Granulocytes: Neutrophils, Eosinophils, Basophils and Tissue Mast Cells CMICells

  4. CTL Antigen Recognition

  5. CD4 & CD8 Sensitize & Effect

  6. CTL Sensitizaton Phase

  7. CTL & MHC

  8. Effector Phase by CTL

  9. CTL & ICAM-1

  10. Cytotoxic T-Cell Binding to Target Cell (figure 16-6, Kuby, 3rd Edition) CTL binding to Target Cell TC = Target Cell for Cytolytic T-Cell Smaller Cell = CTL CTLandTC

  11. CTL Perforin Pore

  12. T-Cell Killing by Induction of Apoptosis(figure 16-8, Kuby, 3rd Edition) Signals Activation of Apoptosis ICE = Interleukin 1 Converting Enzyme CTL&Apop

  13. T-Cell and NK Cell Development

  14. Comparison of T- and NK Cells

  15. Natural Killer Cell Targets and Restriction to Altered-Self(Figure 16-11, Kuby, 3rd Edition) No Killing (Recognized Self; MHC Class I) Target Cell Killed (Did not recognize self; low MHC Class I NKTarget

  16. ADCC Targets

  17. CD28 – B7 Co-stimulators

  18. B7 Melanoma Vaccine

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