1 / 46

Calcium Cycling in Cardiac Cells

Calcium Cycling in Cardiac Cells. Lin Guo-hua. Cardiac E-C coupling. Slow or L-type Ca 2+ Channels (DHPRs). L-type Ca 2+ Channels. Ca 2+ Release Channel of the Sarcoplasmic Reticulum (Ryanodine Receptor). cardiac ryanodin receptor. Physiological and pathophysiological regulation.

velvet
Télécharger la présentation

Calcium Cycling in Cardiac Cells

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Calcium Cycling in Cardiac Cells Lin Guo-hua

  2. Cardiac E-C coupling

  3. Slow or L-type Ca2+ Channels (DHPRs)

  4. L-type Ca2+ Channels

  5. Ca2+ Release Channel of the Sarcoplasmic Reticulum (Ryanodine Receptor)

  6. cardiac ryanodin receptor

  7. Physiological and pathophysiological regulation

  8. Ca2+ Pump of the Sarcoplasmic Reticulum (SERCA)

  9. SERCA

  10. SERCA-PLN complex

  11. Phospholamban (PLN) & Sarcolipin (SLN)

  12. The Ca2+ Pump of the PlasmaMembrane (PMCA)

  13. Sodium/Calcium Exchanger (NCX)

  14. Troponin C (TnC)

  15. Calmodulin (CaM)

  16. Calmodulin (CaM) &Calmodulin Kinase II (CaMKII)

  17. Calmodulin Kinase II (CaMKII)

  18. Regulation of Ca Transporters by CaM and CaMKII

  19. frequency-dependent acceleration of relaxation (FDAR)

  20. Calsequestrin (CSQ)

  21. Organization of EC coupling elements

  22. Integrative Analysis of Calcium Cycling in Cardiac Muscle

  23. [Ca2+]i Transient in Heart Cell

  24. [Ca2+]i sparks & [Ca2+]I Transient

  25. Ca2+ Requirements for Activation of Myofilaments

  26. Autoregulation of SR Ca2+ Content

  27. Modulation of the RyR Changes of sarcolemmal fluxes and SR CaCa2+ release during potentiation of CICR by caffeine (500 mmol/L)

  28. relationships between the various Ca2+ fluxes

  29. Ca2+ Influx During the Cardiac AP

  30. Ca2+ Removal From the Cytosol DuringCardiac Relaxation

  31. Frequency-dependent changes in the fraction of Ca release that is taken back up by the SR

  32. Measurement of SR Ca2+ content and forcefrequency relationship.

  33. force frequency relation

  34. Frequency-dependence of isometric twitch force (twitch) and rapid cooling contractures (RCC) in nonfailing and failing human myocardium

  35. Relationship between NCX and SERCA protein levels and in non-failing and failing human myocardium

  36. Caffeine contractures in isolated rabbit myocytes following adenoviral gene transfer of LacZ and NCX

  37. Frequency-dependent changes in twitch force, aequorin light signals RCCs in huma atrial muscles (A) and ventricular muscles (B).

  38. Steady-state twitches, postrest twitches, and RCCs in isolated human atrial myocardium.

  39. Rapid Cooling Contracture

  40. Paired RCCs and Ca2+Reuptake Into the SR

  41. postrest potentiation & postrest decay Rest-dependent changes in the amplitudes of twitch force and RCCs) in human atrial myocardium (A) and ventricular muscles (B)

  42. restitution postextrasystolic potentiation

  43. Ca2+ Restitution of the Ca transient

More Related