65 alone

1. Supplementary Fig. 1. Degradation kinetics of curcumin compared in PBS as well as in PBS supplemented with BCS (10% v/v). T1/2 of curcumin was found to increase significantly (~40 hrs) in PBS supplemented with BCS as compared to in BCS alone (<30 mins)

2. Supplementary Fig. 2. DSC studies were carried out by heating (6-9 mg of each sample) from 28 °C to 200 °C at a rate of 10 °C (DSC Q20 from TA instruments) under 50 ml/min nitrogen flow. Melting temperature (Tm) of PCL-65 was found to be 60-61 °C and that of curcumin at 177 °C. Only one melting endotherm (of PCL-65) was observed in implants prepared with 10% curcumin load (10 mg per cm implant).

3. PCL-65 alone P - 65 alone Implant with 10% curcumin load Implant with 10% curcumin load Curcumin alone Curcumin alone Supplementary Fig. 3: PXRD studies were carried out by using Bruker AXS D8 Diffractometer. The samples were placed onto polymethylmethacrylate (PMMA) sample holder, leveled manually with a clean glass slide and scanned over an angular range of 5° to 55° 2-theta scale with a step time of 0.2 sec. No crystallization peak characteristic of curcumin was found in implants with 10% drug load, suggesting amorphization of curcumin.

4. Supplementary Fig. 4. Coomasie blue stained gel to show modulation of number of proteins by curcumin delivered via implants.