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Impact of GPBAR1 Modulation on Immune Cell Responses in TNBS-Induced Colitis Models

This study examines the effects of GPBAR1 modulation on various immune cells in the context of TNBS-induced colitis. Specifically, we evaluate the response of CD3+ and CD14+ cells under the influence of Ciprofloxacin and GPBAR1 activation. Results show significant differences in cell populations, suggesting that GPBAR1 plays a crucial role in regulating immune responses during inflammation. Our findings could have implications for therapeutic approaches targeting GPBAR1 in gastrointestinal diseases.

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Impact of GPBAR1 Modulation on Immune Cell Responses in TNBS-Induced Colitis Models

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  1. 2°ab alone GPBAR1+ LPMC Control TNBS + vehicle TNBS + Ciprofloxacin A B E Control TNBS TNBS + Ciprofloxacin C %CD3/GPBAR1+ cells 2,16 ± 0,06 %CD3/GPBAR1+ cells 3,59 ± 0,11 %CD3/GPBAR1+ cells 3,31 ± 0,18 CD3+ cells D %CD14/GPBAR1+ cells 89 ± 3,2 %CD14/GPBAR1+ cells 92 ± 4.5 %CD14/GPBAR1+ cells 84 ± 5.5 CD14+ cells GPBAR1+ cells Figure 5

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