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Type 1 Diabetes Increases the Expression of Proinflammatory Cytokines and

Featured Article :. Type 1 Diabetes Increases the Expression of Proinflammatory Cytokines and AdhesionMolecules in the ArteryWall of Candidate Patients for Kidney Transplantation.

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Type 1 Diabetes Increases the Expression of Proinflammatory Cytokines and

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  1. Featured Article: Type 1 Diabetes Increases the Expression of Proinflammatory Cytokines and AdhesionMolecules in the ArteryWall of Candidate Patients for Kidney Transplantation Javier Triñanes, MSc, Eduardo Salido, M.D., Ph.D., Julián Fernández, M.D., Ph.D., Margartia Rufino, M.D., Ph.D., José Manuel González- Posada, M.D., Ph.D., Armando Torres, M.D., Ph.D., Domingo Hernández, M.D., Ph.D. Diabetes Care Volume 35:427–433 February, 2012

  2. Study Objective • To assess the influence of type 1 diabetes on atheromatosis-related inflammation in patients with chronic kidney disease (CKD) Triñanes J et al. Diabetes Care 2012;35:427-433

  3. Study Design • Analyzed expression of proinflammatory cytokines and adhesion molecules in inferior epigastric artery walls of type 1 diabetic patients with CKD (n = 22) compared with nondiabetic patients with CKD (n = 92) at time of kidney transplantation • Evaluated expression of IL-6, MCP-1, VCAM-1, intercellular adhesion molecule-1, and activation of NFkB-p65 • Common carotid IMT determined by conventional echography Triñanes J et al. Diabetes Care 2012;35:427-433

  4. Triñanes J et al. Diabetes Care 2012;35:427-433

  5. Triñanes J et al. Diabetes Care 2012;35:427-433

  6. Triñanes J et al. Diabetes Care 2012;35:427-433

  7. Triñanes J et al. Diabetes Care 2012;35:427-433

  8. Conclusion • Type 1 diabetes produces a proinflammatory state in arteries of CKD patients, with increased levels of IL-6, MCP-1, and VCAM-1, and more NFkB- p65 activation • Associated with more severe vascular lesions and higher c-IMT • Findings support major role of inflammation in type 1 diabetic patients with CKD Triñanes J et al. Diabetes Care 2012;35:427-433

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