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Lecture 17 Gametogenesis at the Chromosomal level: Mitosis and Meiosis

Lecture 17 Gametogenesis at the Chromosomal level: Mitosis and Meiosis. Animal Science 434 John J. Parrish. Homologous Chromosomes Have the same kind of genes in the same order 1 from father, 1 from mother. Sister chromosomes (X, Y). Definitions. Chromosome - linear DNA molecule .

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Lecture 17 Gametogenesis at the Chromosomal level: Mitosis and Meiosis

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  1. Lecture 17Gametogenesis at the Chromosomal level: Mitosis and Meiosis Animal Science 434 John J. Parrish

  2. Homologous Chromosomes • Have the same kind of genes in the same order • 1 from father, 1 from mother Sister chromosomes (X, Y) Definitions Chromosome - linear DNA molecule Centromere - special region of spindle attachment

  3. Homologous Chromosomes DNA Replication Chromatids Chromatids Definitions A chromatid pair has an identical sequence of DNA

  4. Cell Cycle M Go MPF MPF MPF G1 G2 MPF MPF MPF MPF Interphase S

  5. M - Phase • Prophase • Metaphase • Anaphase • Telophase • Cytokinesis

  6. Grand Scheme Mitosis Meiosis 2N 2N Replicate Division Replicate Division 2N 2N 2N 2N Division N N N N

  7. Go Mitosis G1 M - phase Prophase S G2 Metaphase Homologous chromosomes pair along side of each other Chromatids Centromere MPF high Spindles (microtubules)

  8. Mitosis Anaphase MPF decreases Chromatids pull apart

  9. Mitosis Anaphase MPF decreases Chromatids pull apart

  10. Mitosis Telophase Chromosomes pull apart further Microtubules Disappears Nuclear envelopes reform

  11. Mitosis Telophase Chromosomes pull apart further Microtubules Disappears Nuclear envelopes reform

  12. Mitosis Cytokinesis

  13. 2N 2N Mitosis Cytokinesis

  14. Meiosis 2N 4N Go G1 S G2 Prophase Primary Spermatocyte Primary Oocyte

  15. The Five Phases of Meiotic Prophase • Leptotene • Chromosomes condense 4N • Zygotene • Homologous chromosomesbegin to pair • Bivalents 4N

  16. The Five Phases of Meiotic Prophase • Pachytene • Pairing is completed • Crossing over of homologues occur 4N • Diplotene/Dictyatene • Oocytes stop here before puberty • Homologous chromosomes pull apart but remain attached at crossover points (chiasma) • RNA synthesis is possible 4N

  17. The Five Phases of Meiotic Prophase • Diakinesis • RNA synthesis stops • The chromatids become visible 4N Homologous chromosomes linked at chiasma Chromatids linked at centromere Crossover (chiasma) Centromere

  18. Metaphase I of Meiosis 4N Homologous chromosomes move toward opposite poles and pair across from one another Homologous chromosomes held together via chiasma

  19. Anaphase I of Meiosis 4N Recombination as a result of crossing over

  20. Telophase I 4N

  21. 2N 2N Telophase I Cytokinesis 4N Secondary Spermatocyte orSecondary Oocyte

  22. Meiosis Metaphase II 2N 2N No Replication Rest Same As Mitosis 2N 2N Oocytes stop here until fertilized

  23. Meiosis This does notexist for oocyte Telophase II Cytokinesis Anaphase II N N 2N Spermatid N 2N N

  24. Abnormalities • Anueploidy • Not an exact multiple • Hyper or hypo • Example: 2N - 1 or 2N + 1 • Euploidy • Exact multiple of haploid • Example: 3N, 4N, etc. • Non-disjunction • Causes aneuploidy and occurs in meiosis • Example: N - 1 or N + 1

  25. XX YY XXYY O XY XX O XY Y O O Y XXY XXY XO XO XXX XO XY XY Abnormalities Non-disjunction XXYY XY XXYY X Kleinfelter’s Syndrome Turner’s Syndrome

  26. Down’s Syndrome • Non-disjunction • Extra copy of chromosome 21 • Probability increases with age • Age 35, 2 per 1000 births • Age 40, 6 per 1000 births • Age 45, 16 per 1000 births

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