1 / 28

Infection

Infection. Tumors Grafts. Specificity Memory “Tolerance“. IMMUNITY. “innate resistance“ > 95 % Ab in eggs protective memory via Ab (vaccines) TB: no vaccine autoimmunity > 30 y, female > male 5 : 1. B cell – Ab responses. local mucosal IgA no T / LN / Peyer

wilma
Télécharger la présentation

Infection

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Infection Tumors Grafts Specificity Memory “Tolerance“

  2. IMMUNITY • “innate resistance“ > 95 % • Ab in eggs • protective memory via Ab (vaccines) • TB: no vaccine • autoimmunity > 30 y, female > male 5 : 1

  3. B cell – Ab responses • local mucosal IgAno T / LN / Peyer • Ag + LPS : IgM(no TH) • intact virus : IgM (no TH) • serotypes • monomeric Ag : obligatory TH

  4. reverse genetic glycoprotein exchange between LCMV and VSV rLCMV/INDG rVSV/LCMV-GP glycoprotein:IND-G glycoprotein: LCMV-GP LCMV VSV-IND glycoprotein: LCMV-GP glycoprotein:IND-G

  5. Only VSVG expressing viruses induce a neutralizing antibody response

  6. Immunological memoryQuicker (earlier) Greater (better) responses Immunity Protection against disease by reinfection First infection kills host: No memory needed Host survives first infection: Memory not needed neither

  7. No protection by Memory B cells but protection by immune serum in IFN-aBR_/_ against VSV Anti-VSV neutr. AB < 1 : 40 < 1 : 40 < 1 : 2500 % Survivors 0 0 100 VSVIND immune spleen cells T+B LCMV immune spleen cells VSVIND Ab

  8. Maintenance of protection 1. Agent persists: TB, leprosy, HIV, HCV, LCMV Herpes viruses crippled: measles 2. Repetitive inf.: polio, bact. toxins 3. Antibody-antigen complex depots in lymph nodes and spleens

  9. Vaccines Successpox, polio:IgGmeasles, mumps: IgA, IgG No successTB, leprosy, HIV: Ig + T cells

  10. Poliomyelitis – age distribution in Massachusetts 1912 – 1952

  11. Memory / Pregnant Female • Academic: earlier + higher (AG –) • Immune against cytopathic infectionsotherwise abortions / malformations • MHC-incompatibility – offspringmother: imm. suppr. / offspr.: imm. incomp. • Maternal antibodies attenuate acute infectionsphysiological vaccinations (incl. malaria, eggs) • Non-cytophatic infections transferred via placenta / at birth / after birth (LCMV, HCV, Herpes) • Resistance via T cells: HIV, HTV, TB Lepr. slow • "Emerging" infections

  12. Peripheral solid organs Peripheral lymphatic organs Generalized hematogenic spread Imm. resp. Exempl. Ignor. Papill. V perif. self Protect. Polio V Infl. Antigen dose Infect. imm. TB, HBV, HIV Exhaust. deletion HCV, LDV (HIV, LCMV) 7 >100 7 >100 7 >100 Time of antigen availability (days)

  13. A. Althage M. Bachmann Th. Kündig A. Ciurea U. Karrer Hunziker Recher Pinschewer C. de la Torre H. Hengartner • A. Ochsenbein • B. Ludewig • M. Pericin • HP. Roost • St. Freigang • M. Martinic • Th. Rülicke • Odermatt • M. Whitt

More Related