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ELIGIBILITY: MRC/BHF Heart Protection Study

ELIGIBILITY: MRC/BHF Heart Protection Study. Increased risk of CHD death due to prior disease: Myocardial infarction or other coronary heart disease; Occlusive disease of non-coronary arteries; or Diabetes mellitus or treated hypertension Age 40-80 years

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ELIGIBILITY: MRC/BHF Heart Protection Study

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  1. ELIGIBILITY: MRC/BHF Heart Protection Study • Increased risk of CHD death due to prior disease: • Myocardial infarction or other coronary heart disease; • Occlusive disease of non-coronary arteries; or • Diabetes mellitus or treated hypertension • Age 40-80 years • Total cholesterol >3.5 mmol/l (>135mg/dl) • Statin or vitamins not considered clearly indicated or contraindicated by patient’s own doctors

  2. FACTORIAL TREATMENT COMPARISONS

  3. STATIN USE: Compliance (≥ 80%) with study simvastatin or non-study statin use

  4. Average: - 0.96 ± 0.02 mmol/l - 37 ± 0.8 mg/dl

  5. SIMVASTATIN: Average LDL DIFFERENCE(mmol/l ± se) by BASELINE LDL

  6. (2.6 mmol/l) (3.4 mmol/l)

  7. SIMVASTATIN: Safety monitoring

  8. SIMVASTATIN: Main conclusions • After allowance for non-compliance, 40mg daily simvastatin safely reducesthe risk of heart attack, of stroke, and of revascularisation by at least one-third • 5 years of statin treatment typically prevents these “major vascular events” in about: • 100 of every 1000 with previous MI • 80 " " other CHD • 70 " " diabetes (age 40+) • 70 " " previous stroke • 70 " " other PVD irrespective of cholesterol level (or age, or sex, or other treatments)

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