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Encephalitis B virus

Encephalitis B virus. 马 姝 叶 翔 吕卓珍 吕钊鹏 孙晓君 李 艳 姜 蓉 姜振宇 夏文君 秦伟栋 黄俊霞. Biological properties. Also called Japanese encephalitis virus (flavivirus ) +ssRNA Capsid: Icosahedral symmetry Enveloped Three kinds of structural proteins

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Encephalitis B virus

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  1. Encephalitis Bvirus 马 姝 叶 翔 吕卓珍 吕钊鹏 孙晓君 李 艳 姜 蓉 姜振宇 夏文君 秦伟栋 黄俊霞

  2. Biological properties • Also called Japanese encephalitis virus (flavivirus ) • +ssRNA • Capsid: Icosahedral symmetry • Enveloped • Three kinds of structural proteins E the glycoprotein on the surface of envelope M inner surface of the envelope C the protein of the capsid • Antigenicity stability

  3. Picture of Encephalitis B virus

  4. The course of infection Proliferation in the endothelium of capillary and the regional lymph node the bite of an infected mosquito Little into the blood caused the first viraemia Proliferation in the mono macrophage of the spleen and liver a secondary viraemia Abortive infection some cases the virus crosses the blood brain barrier Encephalitis

  5. Epidemiology • Source of infection and reservior host The major source is domestic animal、poultry pig→mosquito→pig Proliferation in mosquito and transmit to its eggs.The virus lives in the mosquito for ever. • Vector Culex tritaeniorhynchus(三带喙库蚊)、aedes、anopheles • Susceptible people The children under 10 years old is easy to be Infected Life time long immune to the virus

  6. The Piglet

  7. Characteristics of epidemiology • EB only distributes in Asia. • 80～90% case all focus on July ,August, September. South china June～July， north china July～August, northeast August～ September， all identical to the density curve of mosquitoes. • Highly disperse.

  8. Epidemic Region Encephalitis B

  9. Clinical Manifestation • Light type 38～39℃, always consciousness 嗜睡 commonly no twitch,no evident stimulation to meninx ,recovery within a week. • Medium type 40℃or so hard to conscious such as light coma ,sometimes twitch ,last 10days or so . • Severe type above 40℃，coma ，persistently twitch ,may cause failure of respiratory ,manifestation of different extent of mental disorder and paralysis during recovery. • Break-out type high fever ever super high fever, deep coma and repeated strongly twitch,may die due to centrally respiratory failure during very short time ,even survivals often have severe sequelae.

  10. coma above 40℃，coma ，persistently twitch ,may cause failure of respiratory ,manifestation of different extent of mental disorder and paralysis during recovery.

  11. paralysis twitch

  12. Immunity • IgM presents 5~7 days later after infection • IgG hemagglutination inhibition antibody • Neutralization antibody • complement fixation antibody（no protection） • Stable immunity，latent infection also can get the immunity

  13. Microbiological detection • Test for cerebrospinal fluid(CSF) PCR100% specific • Isolation and Identification Necropsy or viral culture using Vero, LLCMK2 and PS cells Serology test Source of false positive :heterologous flaviviral antibody

  14. ELISA Test specific IgM Ab in serum or cerebrospinal fluid • Hemagglutination inhibition test detect IgM antibodes and IgG antibodies • Neutralizing test Early stage:IgM later stage:IgG • Complement binding test

  15. Treatment No specific treatment Interferon-alpha A • Mortality less than 10% Report

  16. Prevention Kill mosquitoes

  17. Inoculation of vaccine live attenuated vaccines Cellculture-derivedinactivatedvaccine (primary hamster kidney cell ) children 6 months----10 years old in epidemic region.

  18. Thank you

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