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Bio-bio-1 Team

Bio-bio-1 Team. Advisor : Dr. Supten Sarbadhikari Members : Fokhruz Z aman Zohirul Alam Tiemoon Saddam Hossain Farjana Khatun. Original definition (1979 by Paulien Hogeweg ): “ application of information technology and computer science to the field of molecular biology”.

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Bio-bio-1 Team

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  1. Bio-bio-1 Team Advisor: Dr. SuptenSarbadhikari Members: FokhruzZaman ZohirulAlamTiemoon Saddam Hossain FarjanaKhatun

  2. Original definition (1979 by PaulienHogeweg): “application of information technology and computer science to the field of molecular biology” Bioinformatics Biological Data Computational Calculation + 2 (c) Mark Gerstein, 1999, Yale, bioinfo.mbb.yale.edu

  3. Derivation: Bio + Informatics Bio Bios (Greek) Life Informatics Informatique (French) Data Processing

  4. Why Use of Bioinformatics Why bioinformatics • To Find an answer quickly -in-silicobiology is faster than in-vitro Massive amounts of data to analyse • Need to make use of all information • Not possible to do analysis by hand • Can’t organise and store information only using lab note books • Automation is key All results of computer analysis should to be verified by biologists

  5. Quantity of each type of data that is currently (August 2000) available

  6. Why Use of Bioinformatics • Biological data are being produced at a unusual rate. • On average, these databases are doubling in size every 15 months • To bring together and store vast amounts of information from •Lab equipment and experiments •Computer Analysis •Human Analysis •Make visible to the world’s scientists Without Bioinformatics, Human Genome Project could not have been achieved !!!

  7. Goals of Bioinformatics Development and implementation of tools that enable efficient access to, and use and management of, various types of information. Development of new algorithms and statistics with which to assess relationships among members of large data sets, such as methods to - locate a gene within a sequence, - predict protein structure and/or function, - uncover the wealth of biological information hidden in the mass of data - obtain a clear insight into the fundamental biological process of organisms. - identify malfunctions in these processes which lead to diseases - find approaches to improving drug discovery.

  8. Bioinformatics Databases • Public databases are the most important entity in bioinformatics • Store knowledge about - Sequence e.g. EMBL - Structure e.g. PDB - Pathways e.g. KEGG - Interactions e.g. DIP - Diseases e.g. OMIM And many others … • Can be searched in a variety of ways e.g. keyword, pattern, sequence

  9. Cycle of Life Structure Function Sequence Evolution KKAVINGEQIRSISDLHQTLKK WELALPEYYGENLDALWDCLTG VEYPLVLEWRQFEQSKQLTENG AESVLQVFREAKAEGCDITIE Ligand

  10. Central Paradigm of Molecular Biology

  11. Central Paradigm of Bioinformatics Genetic Information Molecular Structure Biochemical Function Symptoms

  12. Real world of Bioinformatics 1. Molecular medicine More drug targets Personalized medicine Preventative medicine Gene therapy 2. Microbial genome applications Waste cleanup Climate change Alternative energy sources Biotechnology Antibiotic resistance Forensic analysis of microbes The reality of bio-weapon creation Evolutionary study

  13. 3. Agriculture Crops Insect resistance Improve nutritional quality Grow crops in poorer soils and that are drought resistant 4. Animals 5. Comparative studies

  14. Bioinformatics Challenges • Biological Redundancy and multiplicity • Different sequences with similar structures • Difference structures with similar sequences • Organisms with similar genes • Multiple functions of single gene • Grouping of genes in pathways • Significance of relationships and similarities • Lack of Data

  15. References • http://www.ncbi.nlm.nih.gov/About/primer/bioinformatics.html • What is bioinformatics? An introduction and overview, N.M. Luscombe, D. Greenbaum, M. Gerstein. Department of Molecular Biophysics and Biochemistry Yale University, New Haven, USA • Introduction to BioinformaticsIntroduction Bioinformatics, Stephen Taylor • Intro to BioInformatics, EstiYeger-Lotem, Doron Lipson, Lecture I: Introduction & Text Based Search • Emerging Areas in BIOINFORMATICS, Dr. GulshanWadhwa, National Seminar on "Intellectual Property Rights in Bioinformatics and Biotechnology” September 15 2005 Bioinformatics Centre, Pondicherry University • BIOINFORMATICS Introduction, Mark Gerstein , Yale University bioinfo.mbb.yale.edu/mbb452a • http://www.cs.usfca.edu/~pfrancislyon/resources/cs686_01_intro.pdf • …………….. Some downloaded ppt.

  16. Some Web Related to Bioinformatics • http://bio-bio-1.wikispaces.com • http://www.dnalc.org/ • http://www.bioinformaticsatschool.eu/

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