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DNA Nanorobotics Reem Mokhtar

DNA Nanorobotics Reem Mokhtar. DNA Nanorobotics. Book Chapter: Chandran , H., Gopalkrishnan , N., & Reif , J. ( n.d. ). DNA Nanorobotics . Aim: design and fabrication of dynamic DNA nanostructures that perform specific tasks via a series of state changes (average system behavior).

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DNA Nanorobotics Reem Mokhtar

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  1. DNA NanoroboticsReemMokhtar

  2. DNA Nanorobotics Book Chapter: Chandran, H., Gopalkrishnan, N., & Reif, J. (n.d.). DNA Nanorobotics. Aim: design and fabrication of dynamic DNA nanostructures that perform specific tasks via a series of state changes(average system behavior)

  3. Challenges • Domain to sequence mapping in design (spurious interactions) • Fuel (spontaneous entropic effects) • Assembly + purification • Experimental design for validation ...each step is a challenge Book Chapter: Chandran, H., Gopalkrishnan, N., & Reif, J. (n.d.). DNA Nanorobotics.

  4. Examples in Nature –> Kinesins ATPases(ATP  ADP  energy) Yildiz, A. (2004). Kinesin WalksHand-Over-Hand. Science, 303(5658), 676–678. doi:10.1126/science.1093753 Book Chapter: Chandran, H., Gopalkrishnan, N., & Reif, J. (n.d.). DNA Nanorobotics.

  5. Examples in Nature –> Myosins http://www.dnatube.com/video/389/A-Moving-Myosin-Motor-Protein http://www.youtube.com/watch?v=gJ309LfHQ3M Toyoshima, Y. Y., Kron, S. J., McNally, E. M., Niebling, K. R., Toyoshima, C., & Spudich, J. A. (1987). Myosin subfragment-1 is sufficient to move actin filaments in vitro. Binds to actin  ATP hydrolysis  mechanical movement Book Chapter: Chandran, H., Gopalkrishnan, N., & Reif, J. (n.d.). DNA Nanorobotics.

  6. Why DNA? Design • Predictable geometries can be achieved • Can predict dsDNA thermodynamics + geometry using software • Software-assisted design Book Chapter: Chandran, H., Gopalkrishnan, N., & Reif, J. (n.d.). DNA Nanorobotics.

  7. Why DNA? Experiments • Custom ssDNA synthesis  routine + inexpensive • Assembly simple • Characterization techniques (AFM, TEM, …) Book Chapter: Chandran, H., Gopalkrishnan, N., & Reif, J. (n.d.). DNA Nanorobotics.

  8. Chapter Classification Book Chapter: Chandran, H., Gopalkrishnan, N., & Reif, J. (n.d.). DNA Nanorobotics.

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