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Phosphorylation and Acetylation in Mediator Complex Signaling Pathways

This article explores the intricate roles of Cdk9, Cyclin, and Mediator complexes in signaling pathways, focusing on the phosphorylation and acetylation processes that regulate gene expression. We discuss how Cdk9 and its associated Cyclins, like Cyc, interact with factors such as LARP7 and MEPCE, influencing transcription through the regulation of RNAPII and associated corepressors. Understanding these mechanisms sheds light on the complex interplay of signaling stimuli in transcription regulation.

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Phosphorylation and Acetylation in Mediator Complex Signaling Pathways

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  1. Cdk9 Cyc Hex1 Hex1 Cyc Cdk9 * MEPCE Cdk9 Hex1 Cyc LARP7 Hex1 * MEPCE LARP7 A) Signaling pathways Stimuli C) Phosphorylation ? B) P S5 Acetylation ? Mediator Acetyltransferase Corepressors Ac P S2 DSIF CTD P NELF Brd4 RNAPII +1 Activator *

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