1 / 210

Pharmacology Jeopardy Block 2 - Part I Peter O. Beaumont, M.Sc. (Pharm) St. Vinnie’s Fall 2000

Pharmacology Jeopardy Block 2 - Part I Peter O. Beaumont, M.Sc. (Pharm) St. Vinnie’s Fall 2000. Antibiotics. It is thought that a cell Tx with penicillin may have to produce these in order to be bactericidal. What are… Autolysins

zahi
Télécharger la présentation

Pharmacology Jeopardy Block 2 - Part I Peter O. Beaumont, M.Sc. (Pharm) St. Vinnie’s Fall 2000

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. PharmacologyJeopardy • Block 2 - Part I • Peter O. Beaumont, M.Sc. (Pharm) • St. Vinnie’s Fall 2000

  2. Antibiotics

  3. It is thought that a cell Tx with penicillin may have to produce these in order to be bactericidal

  4. What are… • Autolysins • This is part of the reasoning why you should not mix tetracyclines with cell wall synthesis inhibitors

  5. The estimated rate of resistance of • S. aureus to • penicillin G

  6. What is… • 90% • You should always be cognizant of this when prescribing antibiotics for Staph infections

  7. This ‘prophylactic’ acronym reminds you what drugs to use for many staph infections

  8. What is… • CONDoM • recall, all the penicillins with ‘ox’ in them can be taken orally. • Naficillin, can be oral, but abs is variable • Methicilin is definitely not oral

  9. For P. aeruginosa, choose one of these penicillins

  10. What are… • Mezlocillin • Carbenicillin • Azlocillin • Ticarcillin • Piperacillin

  11. This penicillin is cleared by the kidney, but spends time in the bile, making it useful against this ‘fishy’ organism

  12. What is… • Ampicillin & Salmonella (Carrier state)

  13. This aminopenicillin is not affected by food when taken orally

  14. What is… • Amoxicillin

  15. Penicillin G does not penetrate well into these 3 organs

  16. What are… • The eye, prostate and meninges (uninflammed)

  17. The only penicillin to be used in patients with Renal Failure

  18. What is… • Naficillin • It is the only one cleared mainly be the liver

  19. Match the beta-lactam ADR • Naficillin • Oxacillin • Methicillin • Ampicillin • neutropenia • hepatitis • nephritis • allergic rash in Mono

  20. Fever chills, rigors and arthralgia due to release of spirochete toxins

  21. What is… • The Herxheimer Reaction • Occurs with most spirochetes, and is independent of the antibiotic used

  22. While 1st-Gen Cephs are known for their activity for G-pos, organisms they are still active against these G-negs...

  23. What is… • Proteus mirabilis • Enterobacter • E.coli • Klebsiella pneumoia • Mloraxlla catarrhalis

  24. These drugs have in common the side effect of hypoprothombinemia and a disulfiram-like reaction

  25. What are… • Cefoperazone, Moxolactam and Cefomandole • 3rd, 3rd and 2nd gen agents

  26. The main difference between 3rd and 4th-Gen cephs..,

  27. What is… • more resistance to beta-lactamase • Especially chromosomal lactamase produced by Enterobacter

  28. Type of superinfection likely in 3rd-Gen cephs

  29. What is… • Gram-positive organisms • recall, as you move from 1st to 3rd Gen, there is more G-neg activity and less G-pos activity

  30. Don’t ask me why, but this common lab test may become positive with the use of cephalosporins

  31. What is… • Urine test for glucose • Apparently, this is for all classes of cephs.

  32. The First Gen Cephs

  33. The spectrum of this class of beta-lactams is just like the aminoglycosides

  34. What are… • Monobactams • Active against G-negs • No activity against G-pos or anaerobes • Aztreonam is the only drug in the class

  35. This beta-lactam has the broadest spectrum of all and greatest resistance to lactamase

  36. What is… • Imipenem • Think Omni-potent imipenem • Cilastin makes it resistant to dihydropeptidase in the kidney

  37. The only iv drug studied that is limited solely to • G-pos organisms

  38. What is… • Vancomycin • iv for Tx of MRSA (usually with an aminoglycoside) • po for Tx of C.difficile • one exception is G-neg Flavobacterium - but I don’t think we studied it

  39. This antibiotic works only in the periplasmic space

  40. What is… • Bacitracin • Interferes with cycling of the lipid transporter Bactoprenol • too toxic for systemic use • G-pos organisms only

  41. Inhibits the conversion of L-ala to D-ala

  42. What is… • Cycloserine • Inhibits alanine racemase • almost exclusively used as 2nd line Tx for TB due to toxicity • “Psycho-serine”

  43. Sulfas used in bowel-prep, based on the absorption profile

  44. What are… • Phthalylsulfathiazole Succinylsulfathizole and Sulfaquanine • Neomycin is also effective in this regard

  45. Acidity in the urine causes precipitation of this drug class

  46. What are… • Sulfa drugs

  47. Mechanisms of resistance to sulfa drugs...

  48. What are… • decreased affinity for dihydropteroate synthase • overproductoin of PABA • increased acetylation • Plasmid mediate

  49. The crossing of unconjugated bilirubin into the CNS in newborns

  50. What is… • kernicterus • Occurs in sulfonamides and other drugs that are normally highly bound to albumin in adults

More Related