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Chromosomal Basis of Inheritance

Chromosomal Basis of Inheritance. chromosome theory of inheritance. Mendelian genes have specific loci (positions) on chromosomes It is the chromosomes that undergo segregation and independent assortment. Morgan’s Experiment. fruit flies

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Chromosomal Basis of Inheritance

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  1. Chromosomal Basis of Inheritance

  2. chromosome theory of inheritance • Mendelian genes have specific loci (positions) on chromosomes • It is the chromosomes that undergo segregation and independent assortment

  3. Morgan’s Experiment • fruit flies • chromosomes are the location of Mendel’s heritable factors

  4. Linked genes • Genes located on the same chromosome that tend to be inherited together • Can be broken by crossing over

  5. Linkage Map • genetic map of a chromosome based on recombination frequencies • Distances between genes can be expressed as map units; one map unit, or centimorgan, represents a 1% recombination frequency • Map units indicate relative distance and order, not precise locations of genes

  6. chromosomal basis of sex determination

  7. Sex-linked Genes • Some disorders caused by recessive alleles on the X chromosome in humans: • Color blindness • Duchenne muscular dystrophy • Hemophilia

  8. Abnormal Chromosome number • Nondisjunction • Aneuploidy results from the fertilization of gametes in which nondisjunction occurred • Trisomy • Monosomy • Polypoidy

  9. Alterations of Chromosome structure

  10. Human Disorders • Down Syndrome • Klinefelter syndrome – XXY • Turner - XO

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