'Complex traits' diaporamas de présentation

MULTIFACTORIAL INHERITANCE

MULTIFACTORIAL INHERITANCE. Polygenic traits are controlled by two or more genes . Examples: color of skin, hair and eyes . They c ause slight and often variable range of differences throughout population.

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Are male or female animals larger?

Are male or female animals larger?. Note taking tips. Create your own short hand Write down what makes sense to you. Review. Turn to a partner and tell them 3 big ideas you learned last class!. Natural Selection. Inference 1: Fight for survival

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Chapter 8 Inheritance, Genes & Chromosomes

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Tim Aitman

Tim Aitman. 1 st Imperial BHF Symposium, June 5 th 2009 PROFITING FROM GENOMICS. Physiological Genomics and Medicine MRC Clinical Sciences Centre Hammersmith Hospital Imperial College London. Identification of Genes underlying Mendelian and Complex Traits 1980-2002. Mendelian traits.

553 views • 44 slides

Complex Genetic Traits

Complex Genetic Traits. Kate Garber Director of Education Emory University Dept. of Human Genetics kgarber@genetics.emory.edu. Objectives. Understand the concept of threshold liability and the complex interplay of genes and environment in determining many heritable traits

717 views • 42 slides

QTL analysis / Mutagenesis

Genetic basis of atherosclerotic organ damage: From animal genetics to human cohorts. QTL analysis / Mutagenesis. atherosclerosis renal damage HDL cholesterol PLTP activity. candidate genes. functional studies. functional studies. Human populations. Principle of QTL analysis (1).

585 views • 39 slides

Human Gene Mapping and Disease Gene Identificaton

Human Gene Mapping and Disease Gene Identificaton. Paul Coucke Jan Hellemans Andy Willaert. 10. Chapter. Chapter 10. The genetic landscape of the human genome Mapping human genes by linkage analysis Mapping of complex traits From gene mapping to gene identification. Aims.

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Harry Potter and the not so simple world of genetics

Harry Potter and the not so simple world of genetics. Rules of Inheritance. Some traits follow the simple rules of Mendelian inheritance of dominant and recessive genes. Complex traits follow different patterns of inheritance that may involve multiple genes and other factors. For example:

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SNPedia

SNPedia. The SNPedia website http://www.snpedia.com/index.php/SNPedia A thank you from SNPedia http://snpedia.blogspot.com/2012/12/o-come-all-ye-faithful.html Class website for SNPedia http:// stanford.edu/class/gene210/web/html/projects.html List of last years write-ups

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Complex Traits

Complex Traits. Most neurobehavioral traits are complex Multifactorial Polygenic Multigenic QTL: quantitative trait locus Region of a chromosome that contains a gene(s) with different alleles that contributes quantitatively to the variance in a trait.

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Genetics and Personality

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How to avoid pseudoscience and fight misinformation

How to avoid pseudoscience and fight misinformation. Cynthia Bulik, PhD University of North Carolina at Chapel Hill. Embrace Complexity.

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Predisposition to asthma among the Utah population

Predisposition to asthma among the Utah population. Craig Teerlink University of Utah Department of Biomedical Informatics Asthma Genomics Conference Utah Department of Health Asthma Program June 7, 2007. Introduction. Asthma is a common disorder Effects 7% of US population 1

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Molecular Genetics 2010 Welcome to the course!

Molecular Genetics 2010 Welcome to the course!. Molecular Genetics 2008 Welcome to the course!. Describes the use of Molecular Genetics to study a range of different topics

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Human Quantitative Traits

Human Quantitative Traits. By: Francesco Bartucci and Adnan Sator. What are Human Quantitative Traits?. A human q uantitative t rait is a measureable trait that shows a continuous variation and can have numerical values that can be ordered from highest to lowest.

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The Role of Epistasis in the Control of Complex Traits

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Genetic Mapping

Genetic Mapping. Oregon Wolfe Barley Map (Szucs et al., 2009. The Plant Genome 2, 134-140). Genetic Maps. A genetic map or linkage map is a representation (table or figure) of the position of genes (or markers) within a linkage group.

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How to catch epistasis: theory and practice

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What is causation in genetic studies?

What is causation in genetic studies?. Grier P Page Section on Statistical Genetics Department of Biostatistics University of Alabama at Birmingham. Genes for over 1300 Mendelian traits have been identified. Few genes for complex traits have been reproducibly identified (less than 40).

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Genome Scale Family Based Association Testing using Condor

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