slide1 n.
Skip this Video
Loading SlideShow in 5 Seconds..
neurofilament, light polypeptide PowerPoint Presentation
Download Presentation
neurofilament, light polypeptide

neurofilament, light polypeptide

0 Vues Download Presentation
Télécharger la présentation

neurofilament, light polypeptide

- - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript

  1. NEFL L.htm neurofilament, light polypeptide BackgroundNeurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains.;Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role;in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations;in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous;system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. SynonymsNEFL; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; neurofilament light polypeptide; CMT1F; CMT2E; NF68; NFL; neurofilament subunit NF-L; neurofilament triplet L protein; neurofilament protein, light chain; light molecular weig Recombinant Proteins Native Proteins Cell & Tissue Lysates Cat.# Product name Source (Host) Species NEFL-1472M Recombinant Mouse NEFL Protein (2-543 aa), His-tagged Yeast Mouse His +Inquiry NEFL-1292H Recombinant Human NEFL Protein, His-SUMO/MYC-tagged E. coli Human His-SUMO/MYC NEFL-1255H Recombinant Human NEFL, His-tagged His +Inquiry NEFL-12H Recombinant Human NEFL, GST-tagged Human GST +Inquiry NEFL-13H Recombinant Human NEFL protein, MYC/DDK-tagged HEK293 Human MYC/DDK +Inquiry NEFL-182H Recombinant human NEFLE. coli Human NEFL-26033TH Recombinant Human NEFL, His-tagged Human His +Inquiry NEFL-10563M Recombinant Mouse NEFL Protein Mammalian Cells His +Inquiry Nefl-10M Recombinant Mouse Nefl protein, His-tagged His +Inquiry NEFL-3952R Recombinant Rat NEFL ProteinMammalian Cells +Inquiry NEFL-2996R Recombinant Rhesus monkey NEFL Protein, His-tagged Mammalian Cells Rhesus Macaque TagPrice +Inquiry E. coli Human Wheat germ +Inquiry E. coli Mouse E. coli Mouse RatHis His +Inquiry

  2. Involved Pathway NEFL involved in several pathways and played different roles in them. We selected most pathways NEFL participated on our site, such as Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with NEFL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway NamePathway Related Protein Amyotrophic lateral sclerosis (ALS)APAF1; GRIN2B; MAP2K6; CCS; GRIN2D; BID; CASP12; CYCS; GRIN2C; CAT Protein Function NEFL has several biochemical functions, for example, identical protein binding, phospholipase binding, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEFL itself. We selected most functions NEFL had, and list some proteins which have the same functions with NEFL. You can find most of the proteins on our site. FunctionRelated Protein Function identical protein bindingRelated Protein HSPB8; GCG; ALCAMB; POU3F2; PRPS2; CD28; SERPINA1; PTPRG; NUP153; GLE1 Function phospholipase bindingRelated Protein WAS; PARK2; NEFL; DGKQ; ARHGAP6; CALM2; PDPK1; SELE; SERPINB1A; CALM3 Function protein C-terminus bindingRelated Protein ZBTB16; TOP2B; CDC37; HESX1; ATP2A2; RBFOX1; ECM1; DLG3; ERBB2; JAK2 Function protein bindingRelated Protein CUTA; NRCAM; BIRC5; GEMIN8; DMBT1; IL6ST; HADHA; MOB1A; USO1; Ctsl Function protein binding, bridgingRelated Protein NEFL; FSCN2; FGG; CAV1; ST13; CSTA; ANK2; LOR; FGB; FSCN3 Function protein domain specific bindingRelated Protein CENPJ; TJP1; TNNI3; CNOT1; HIST2H4; HIST1H4I; MTOR; VPS11; FOXA2; KCNN2 Function protein heterodimerization activityRelated Protein BMP7A; CXCL13; TERF1; PPARD; TYRO3; CEBPE; RELA; RARA; BOK; IL12B Function structural constituent of cytoskeletonRelated Protein TUBGCP5; SPTA1; TUBGCP2; ACTL6B; KRT17; KRT20; F-KER; SPTBN1; TUBA1L; ARPC5 Interacting Protein NEFL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEFL here. Most of them are supplied by our site. Hope this information will be useful for your research of NEFL. APP; PPP1R18; TERF1; MTMR2; tax; TNF; YWHAG; SCHIP1; PHLPP1; VIM; RAN; CHD3