1 / 3

growth hormone receptor

growth hormone receptor ;growth hormone receptor

Benmoney123
Télécharger la présentation

growth hormone receptor

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. ghr  Official Full Name  growth hormone receptor  Background  This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]  Synonyms  GHR; growth hormone receptor; GHBP; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein;  Recombinant Proteins  Cell & Tissue Lysates Cat.# Product name Source (Host) Species Tag Price GHR-2401MCL Recombinant Mouse GHR cell lysate HEK293 Mouse +Inquiry GHR-1140RCL Recombinant Rat GHR cell lysate HEK293 Rat +Inquiry Involved Pathway GHR involved in several pathways and played different roles in them. We selected most pathways GHR participated on our site, such as Cytokine-cytokine receptor interaction, Neuroactive ligand- receptor interaction, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GHR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

  2. Pathway Name Pathway Related Protein Cytokine-cytokine receptor interaction FLT1; KDRL; FAS; MPL; CCL16; XCL2; EDA; TNFSF9; EDA2R; CCL28 Neuroactive ligand-receptor interaction HTR2A; PRLHR2A; GABRQ; BDKRB2; AGTR2; GRM3; F2RL2; KISS1RA; FPR1; RXFP2A PIK-Akt signaling pathway GNB4; IL6R; PIK3R3; GNG7; INS2; ITGB6; PIK3CD; PRKAA2; CREB3L3; ITGA7 Jak-STAT signaling pathway IL22RA2; CSH2; FHL1A; STAT4; HRASA; CCND2A; Gh; GM13305; SOS1; LIF Protein Function GHR has several biochemical functions, for example, cytokine receptor activity, growth factor binding, peptide hormone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GHR itself. We selected most functions GHR had, and list some proteins which have the same functions with GHR. You can find most of the proteins on our site. Function Related Protein Function cytokine receptor activity Related Protein CRFB15; IL2RGB; CRFB4; Il4ra; IL12RB1; FLT3; IRX1; PRLRA; IL15RA; IL31RA Function growth factor binding Related Protein GHR; LTBP4; IGFBP2B; ACVR2A; FLT4; GHRHR; A2M; RHBDF1; OSMR; BMPR2 Function peptide hormone binding Related Protein HCRTR2; GHRHR; PTH1R; PRLR; NPR1; INHBA; OXTR; GALR2; GHSR; ACVR1 Function proline-rich region binding Related Protein GAREM; TCERG1; CSK; FAM59A; BAIAP2; PRPF40A; WBP4; BAIAP2L1; NEDD4; RABAC1 Function protein binding Related Protein RALGDS; ANKS4B; TSTD2; RTKN; BAHD1; SLAMF7; C2orf62; TPRKB; TBX15; UBE2H Function protein homodimerization activity Related Protein CBX1; DMBX1; DPYD; GCA; SLC26A5; NFS1; MCL1A; HOGA1; KCNE2; CEBPA Function protein kinase binding Related Protein FOXM1; FAF1; HNRNPA0; TBC1D14; CNTLN; SV2A; LAT; JTB; MVP; RHEB Interacting Protein GHR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GHR here. Most of them are supplied by our site. Hope this information will be useful for your research of GHR. PTPRB; PTPN2; PTPN1; PTPN3

  3. GHR Related Articles Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015). Beckwith, H; Yee, D; et al. INSULIN-LIKE GROWTH FACTORS, INSULIN, AND GROWTH HORMONE SIGNALING IN BREAST CANCER: IMPLICATIONS FOR TARGETED THERAPY. ENDOCRINE PRACTICE 20:1214-1221(2014).

More Related