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The Complete Guide to Know How New-found Stem Cell Helps Regenerate Lung Tissue - Creative Bioaray
CONTENTS 01.Brief Introduction 02.Experiment Situation 03.The Application 04. Prospect
PART ONE Brief Intrduction
Brief Introduction The development of the lung is an evolutionary adaption to life on land. In order to survive on land, the lungs are necessary for most large animals. Its complex structure is partly determined by its integration with the cardiovascular system, which makes it an attractive organ that is difficult to study from a perspective of regenerative medicine. In addition, lung disease is one of the leading causes of death in the world, second only to cardiovascular disease and cancer.
Brief Introduction In a new study, researchers from the Perelman School of Medicine at the University of Pennsylvania identified a lung progenitor cell that repairs alveoli (a gas exchange compartment in the lungs). They isolated these progenitor cells from mice and human lungs, described their characteristics, and confirmed that they are essential for lung tissue damage caused by severe flu and other respiratory diseases. Related research results were published online in the Journal of Nature.
PART TWO Experiment Situation
Experiment Situation Morrisey, leader of the research, the a professor of Cell and Developmental Biology and director of the Penn Center for Pulmonary Biology and scientific director of the Institute for Regenerative Medicine One of the most important parts of understanding lung regeneration is the alveoli, the blood in the lungs that absorbs oxygen and the tiny ticks that exhale carbon dioxide. To better understand these subtle structures, we have been drawing different types of cells in the alveoli. Understanding cell-cell interactions should help us discover new players and molecular pathways that will provide targets for future treatments.
Experiment Situation This study explored whether epithelial cells on the alveolar surface have stem cell behavior that may restore normal respiratory function after serious injury caused by influenza infection or in diseases such as chronic obstructive pulmonary disease (COPD). organs such as the lungs show a very slow replacement and contain stem cells that are only activated when they are damaged to regenerate this damaged tissue. Although some organs, such as the intestine, replace the entire intestinal epithelial wall with the resident stem cells every five days.
PART THREE The Application
Application The Morrisey team identified an alveolar epithelial progenitor (AEP), in which the AEP was shed in larger cell populations known as alveolar type 2 cells (AT2 cells). 1 2 Dr. Will Zacharias, co-author of the paper and a postdoctoral researcher at Morrisy Labs, said, ‘AEP is a stable cell lineage in the lung that changes slowly, but rapidly proliferates after injury, regenerating the alveolar walls and restoring gas exchange.’ 4 3 These cells produce pulmonary surfactant (wetting agent) that prevents the lungs from collapsing with each breath.
Application AEPs exhibit their own unique set of genes and contain unique epigenetic markers. The Morrisey laboratory used the genomic information obtained from mouse AEPs to identify a conserved cell surface protein called TM4SF1 and ultilize this protein to separate AEP from human lungs. The Morrisey team then developed a three-dimensional lung organoid by taking advantage of the ability to isolate mouse AEP and human AEP. Mprrisy claimed that, ‘From our organ-like culture system, we were able to confirm that AEP is an evolutionarily conserved alveolar progenitor cell that represents a new target for human lung regeneration strategies.’
PART FOUR Prospect
Prospect Given the severity of the current influenza season, this study provides new insights into human lung regeneration and provides new important genetic and epigenetic pathways for lung regeneration. In the further study, the Morrisey team aimed to study influenza-induced lung tissue injury and other lung disease models to determine where and when AEP responds to acute lung injury or more chronic conditions . A B 添加标题 including understanding whether activating Fgf signaling (one of the key pathways conserved in mouse AEP and human AEP) may promote lung regeneration. D C The Morrisey team is now exploring which of these molecular pathways may contribute to the function of AEP in mice and human lungs
Reporter: Chelsea Clark - Creative Bioarray
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